The Hepatokine FGF21 Increases the Human Spermatozoa Motility.
FGF21 (fibroblast growth factor 21)
fertility
human
metabolism diseases
sperm moTility
spermatozoa
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
09
2021
accepted:
25
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
23
4
2022
Statut:
epublish
Résumé
Lifestyle, environment and excess body weight are not only associated with an increased risk of metabolic disorders, such as type 2 diabetes, but also to other pathological processes, such as infertility. A hormone produced mainly by the liver called fibroblast growth factor 21 (FGF21) is closely linked to the energy status and is increased in patients suffering from obesity or insulin resistance. Recently, FGF21 has been shown to be associated with female fertility disorders, but no or few data about the role of FGF21 on human male fertility has been described. In the present study, FGF21 was measured in the seminal fluid at a lower level in comparison to the blood level. Thus, in the present
Identifiants
pubmed: 35282437
doi: 10.3389/fendo.2022.775650
pmc: PMC8908098
doi:
Substances chimiques
fibroblast growth factor 21
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
775650Informations de copyright
Copyright © 2022 Bourdon, Estienne, Chevaleyre, Ramé, Guérif, Brun, Vasseur, Fromont, Plotton, Dufour-Rainfray, Caldas-Silveira, Dupont, Froment and Ducluzeau.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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