True hyponatremia in the setting of pegasparagase-induced hypertriglyceridemia: A case report.
Asparaginase
Hypertriglyceridemia
Hyponatremia
Pegasparagase
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
01 Jun 2022
01 Jun 2022
Historique:
received:
07
02
2022
revised:
23
02
2022
accepted:
25
02
2022
pubmed:
15
3
2022
medline:
7
6
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
Pegasparagase (PEG-Asparaginase) induced hypertriglyceridemia is rare in the treatment of lymphoblastic lymphoma in children. We present a case of PEG-asparaginase induced hypertriglyceridemia that was incidentally identified and suspicion of its interference with sodium measurement in the clinical laboratory. The use of a direct ion selective method clarified the presence of true hyponatremia. The patient was treated with an oral Fenofibrate therapy which resolved the hypertriglyceridemia. This case highlights that PEG-asparaginanse and Olazanpine can induce hypertriglyceridemia in acute lymphoblastic leukemia and it may be useful to obtain baseline triglyceride measurements for these patients.
Identifiants
pubmed: 35283095
pii: S0009-8981(22)00076-6
doi: 10.1016/j.cca.2022.02.017
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Polyethylene Glycols
3WJQ0SDW1A
Asparaginase
EC 3.5.1.1
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
68-70Informations de copyright
Copyright © 2022. Published by Elsevier B.V.