Four new withanolides with anti-inflammatory activity from Datura inoxia Mill. leaves.

Animals Anti-Inflammatory Agents / chemistry Datura / chemistry Datura metel / chemistry Mice Plant Leaves / chemistry RAW 264.7 Cells Withanolides / chemistry
Anti-inflammatory activities Datura inoxia Solanaceae Withanolide

Journal

Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536

Informations de publication

Date de publication:
06 2022
Historique:
received: 03 12 2021
revised: 06 03 2022
accepted: 08 03 2022
pubmed: 15 3 2022
medline: 20 4 2022
entrez: 14 3 2022
Statut: ppublish

Résumé

Four previously undescribed withanolides, datinolides A-D (1-4) and eight known withanolides (5-12), were separated from the 70% ethyl alcohol extract of Datura inoxia Mill. leaves. All structures were clarified by comprehensive spectroscopic analysis. Furthermore, all withanolides were assessed for their anti-inflammatory activity and results showed that 1 exhibited a fairly good suppression against nitric oxide generation in lipopolysaccharide-stimulated RAW 264.7 cells (IC

Identifiants

DOI: 10.1016/j.steroids.2022.109010 PMID: 35283117
pubmed: 35283117
pii: S0039-128X(22)00048-4
doi: 10.1016/j.steroids.2022.109010
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Withanolides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109010

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Jia-Tong Wu (JT)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Yan Liu (Y)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Si-Yi Wang (SY)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Yi-Kai Jiang (YK)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Xiao-Mao Li (XM)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Anam Naseem (A)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Wei Guan (W)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Juan Pan (J)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.

Hai-Xue Kuang (HX)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China. Electronic address: hxkuang@yahoo.com.

Bing-You Yang (BY)

Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China. Electronic address: ybywater@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Datura › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Datura › Datura metel › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Four new withanolides with anti-inflammatory...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Phytostérols › Withanolides › Four new withanolides with anti-inflammatory...