Molecular docking and in vitro analysis of phytoextracts from B. serrata for antibacterial activities.
GCMS
Molecular docking
Plant extract
bioactive compounds
Journal
Bioinformation
ISSN: 0973-2063
Titre abrégé: Bioinformation
Pays: Singapore
ID NLM: 101258255
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
04
2021
revised:
07
07
2021
accepted:
10
07
2021
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
The bioactives of Boswellia serrata have a role in ulcer healing therapies. Eleven bioactive compounds were obtained by GC-MS among which Cholan-24-oic acid, 3,12-bis (acetyl oxy) has a high molecular weight of 490.6719 with a retention time of 26.729. Twenty wound samples were collected aseptically from the labs and hospitals in and around the Namakkal districts of Tamilnadu, India. The antibacterial potential of E.coli showed a maximum inhibition of 27 mm against Tetracycline at 30µg. The ethanolic extract of the B. serrata shows a susceptibility of 19mm towards E. coli at 60µg concentration in MIC. Molecular docking results show the binding energy of Cholan-24-oic acid, 3,12-bis(acetyloxy) -8.6 (kcal/mol) followed by Pyrene, hexadecahydro- -6.7 (kcal/mol), and 5(1H)- Azulenone, 2,4,6,7,8,8a-hexahydro-3,8-dimethyl-4-(1-methylethylidene)-, (8S-cis)- 6.4 (kcal/mol) for further consideration.
Identifiants
pubmed: 35283584
doi: 10.6026/97320630017667
pii: 97320630017667
pmc: PMC8882077
doi:
Types de publication
Journal Article
Langues
eng
Pagination
667-672Informations de copyright
© 2021 Biomedical Informatics.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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