Advances in the Study of Bacterial Toxins, Their Roles and Mechanisms in Pathogenesis.
bacteria
mechanisms
pathogenesis
toxin
Journal
The Malaysian journal of medical sciences : MJMS
ISSN: 1394-195X
Titre abrégé: Malays J Med Sci
Pays: Malaysia
ID NLM: 101126308
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
07
01
2021
accepted:
20
03
2021
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
ppublish
Résumé
Pathogenic bacteria use various mechanisms to cause infections in the host. Bacterial pathogens express a wide range of molecules. Bacterial toxins have a poisonous substance created and secreted at the extracellular or intracellular level, making these bacteria pathogenic. Two common types of toxins, including exotoxins and endotoxins, have numerous modes of action. Toxin-antitoxin (TA) modules act on their bacterial cells during stressed conditions and help their remaining population survive. Cytolethal distending toxins (CDTs) are genetic, modulating the eukaryotic cell cycle and targeting the immune system of the host. This review discusses toxins and recent discoveries about the mechanisms involved in the pathogenesis of the TA system and CDTs in pathogenic bacteria.
Identifiants
pubmed: 35283688
doi: 10.21315/mjms2022.29.1.2
pii: 02mjms2901_ra
pmc: PMC8887987
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4-17Informations de copyright
© Penerbit Universiti Sains Malaysia, 2022.
Déclaration de conflit d'intérêts
Conflict of Interest None.
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