The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations.
aging
endoplasmic reticulum unfolded protein response
mitochondrial unfolded protein response (UPRmt)
neurodegeneration
unfolded protein response (UPR)
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
12
2021
accepted:
26
01
2022
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health. To this end, two cellular compartments with essential protein folding functions, the endoplasmic reticulum (ER) and the mitochondria, are equipped with unique protein stress responses, known as the ER unfolded protein response (UPR
Identifiants
pubmed: 35283733
doi: 10.3389/fnmol.2022.831116
pmc: PMC8914544
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
831116Informations de copyright
Copyright © 2022 Wodrich, Scott, Shukla, Harris and Giniger.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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