EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.
Dosimetry
Lutetium-177
Neuroendocrine
PSMA-targeting ligands
Prostate adenocarcinoma
Somatostatin-receptor ligands
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
04
11
2021
accepted:
13
02
2022
pubmed:
15
3
2022
medline:
21
4
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular for the treatment of metastatic neuroendocrine tumours using ligands for somatostatin receptors and prostate adenocarcinoma with small-molecule PSMA-targeting ligands. This paper provides an overview of reported dosimetry data for these therapies and summarises current knowledge about radiation-induced side effects on normal tissues and dose-effect relationships for tumours. Dosimetry methods and data are summarised for kidneys, bone marrow, salivary glands, lacrimal glands, pituitary glands, tumours, and the skin in case of radiopharmaceutical extravasation. Where applicable, taking into account the present status of the field and recent evidence in the literature, guidance is provided. The purpose of these recommendations is to encourage the practice of patient-specific dosimetry in therapy with 177Lu-labelled compounds. The proposed methods should be within the scope of centres offering therapy with 177Lu-labelled ligands for somatostatin receptors or small-molecule PSMA.
Identifiants
pubmed: 35284969
doi: 10.1007/s00259-022-05727-7
pii: 10.1007/s00259-022-05727-7
pmc: PMC9015994
doi:
Substances chimiques
Ligands
0
Radioisotopes
0
Radiopharmaceuticals
0
Receptors, Somatostatin
0
Somatostatin
51110-01-1
Lutetium
5H0DOZ21UJ
Lutetium-177
BRH40Y9V1Q
Prostate-Specific Antigen
EC 3.4.21.77
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1778-1809Subventions
Organisme : Cancerfonden
ID : 180747
Organisme : Cancerfonden
ID : 211754Pj01H
Organisme : Fru Berta Kamprads Stiftelse
ID : FBKS-2020-13
Informations de copyright
© 2022. The Author(s).
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