One-year cognitive follow-up of COVID-19 hospitalized patients.
COVID-19
cognition
long-COVID
neuropsychological evaluation
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
12
02
2022
received:
19
01
2022
accepted:
03
03
2022
pubmed:
15
3
2022
medline:
15
6
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
Cognitive dysfunction has been observed following recovery from COVID-19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and eventual associations with specific clinical variables. Seventy-six patients (aged 22-74 years) who had been hospitalized for COVID-19 were recruited. Patients received neuropsychological assessments at 5 (n = 76) and 12 months (n = 53) from hospital discharge. Over half (63.2%) of the patients had deficits in at least one test at 5 months. Compared to the assessment at 5 months, verbal memory, attention and processing speed improved significantly after 1 year (all p < 0.05), whereas visuospatial memory did not (all p > 0.500). The most affected domains after 1 year were processing speed (28.3%) and long-term visuospatial (18.1%) and verbal (15.1%) memory. Lower PaO Our study expands the results from previous studies showing that cognitive impairment can still be observed after 1 year. Patients with severe COVID-19 should receive periodic cognitive follow-up evaluations, as cognitive deficits in recovered patients could have social and occupational implications.
Sections du résumé
BACKGROUND AND PURPOSE
Cognitive dysfunction has been observed following recovery from COVID-19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and eventual associations with specific clinical variables.
METHODS
Seventy-six patients (aged 22-74 years) who had been hospitalized for COVID-19 were recruited. Patients received neuropsychological assessments at 5 (n = 76) and 12 months (n = 53) from hospital discharge.
RESULTS
Over half (63.2%) of the patients had deficits in at least one test at 5 months. Compared to the assessment at 5 months, verbal memory, attention and processing speed improved significantly after 1 year (all p < 0.05), whereas visuospatial memory did not (all p > 0.500). The most affected domains after 1 year were processing speed (28.3%) and long-term visuospatial (18.1%) and verbal (15.1%) memory. Lower PaO
CONCLUSION
Our study expands the results from previous studies showing that cognitive impairment can still be observed after 1 year. Patients with severe COVID-19 should receive periodic cognitive follow-up evaluations, as cognitive deficits in recovered patients could have social and occupational implications.
Identifiants
pubmed: 35285122
doi: 10.1111/ene.15324
pmc: PMC9111730
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2006-2014Informations de copyright
© 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
Références
Science. 1991 Sep 20;253(5026):1380-6
pubmed: 1896849
J Am Geriatr Soc. 2021 Oct;69(10):2778-2780
pubmed: 34019707
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Minerva Anestesiol. 2020 Jun;86(6):678-679
pubmed: 32401000
Ophthalmic Physiol Opt. 2014 Sep;34(5):502-8
pubmed: 24697967
Int J Geriatr Psychiatry. 2012 Jun;27(6):612-20
pubmed: 21766337
N Engl J Med. 2020 Jun 4;382(23):2268-2270
pubmed: 32294339
JAMA Neurol. 2020 Aug 1;77(8):1018-1027
pubmed: 32469387
Neuron. 2020 Jul 22;107(2):219-233
pubmed: 32640192
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
BMJ. 2021 Jul 26;374:n1648
pubmed: 34312178
Am J Respir Crit Care Med. 2012 Jun 15;185(12):1307-15
pubmed: 22492988
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Crit Care. 2019 Nov 12;23(1):352
pubmed: 31718695
Restor Dent Endod. 2013 Feb;38(1):52-4
pubmed: 23495371
Neurol Sci. 2015 Apr;36(4):585-91
pubmed: 25380622
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13438-44
pubmed: 8942954
Eur J Neurol. 2022 Jul;29(7):2006-2014
pubmed: 35285122
J Neurol. 2021 Dec;268(12):4422-4428
pubmed: 33932157
J Psychosom Res. 2008 Sep;65(3):229-38
pubmed: 18707945
Br J Anaesth. 2021 Jan;126(1):44-47
pubmed: 33187638
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
J Nucl Med. 2021 Jul 1;62(7):910-915
pubmed: 33789937
Ann Clin Transl Neurol. 2020 Nov;7(11):2221-2230
pubmed: 33016619
Brain Inj. 2006 Mar;20(3):263-71
pubmed: 16537268
Hippocampus. 1993;3 Spec No:19-26
pubmed: 8287096
Intensive Care Med. 2016 May;42(5):725-738
pubmed: 27025938
Brain Sci. 2021 Feb 13;11(2):
pubmed: 33668456
Brain. 2021 May 7;144(4):1263-1276
pubmed: 33822001
Brain Behav Immun. 2022 Mar;101:93-135
pubmed: 34973396
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Crit Care Med. 2013 Sep;41(9 Suppl 1):S81-98
pubmed: 23989098
J Neurol Neurosurg Psychiatry. 2021 May;92(5):567-568
pubmed: 33219042
Brain Behav Immun Health. 2020 Dec;9:100163
pubmed: 33111132
Eur Neuropsychopharmacol. 2021 May;46:39-48
pubmed: 33823427
Mult Scler. 2006 Dec;12(6):787-93
pubmed: 17263008
Exp Pathol. 1991;42(4):205-12
pubmed: 1959580
Eur J Neurol. 2020 Sep;27(9):1727-1737
pubmed: 32558002
Am J Respir Crit Care Med. 1999 Jul;160(1):50-6
pubmed: 10390379
J Psychiatr Res. 2020 Oct;129:98-102
pubmed: 32912598
J Intern Med. 2021 Sep;290(3):621-631
pubmed: 33533521