HUMAN STUDY


Journal

Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463

Informations de publication

Date de publication:
09 2022
Historique:
pubmed: 15 3 2022
medline: 12 10 2022
entrez: 14 3 2022
Statut: ppublish

Résumé

A previous exploratory analysis of a COMT gene single-nucleotide polymorphism (SNP) and a DRD3 SNP by our group suggested possible contributions to pain-related acute care utilization in people with sickle cell disease (SCD). Our aim was to extend the analysis to gene-spanning haplotypes of COMT SNPs and DRD3 SNPs to investigate possible associations with pain intensity and pain-related acute care utilization in an SCD cohort. Genotyping was conducted, and clinical data were collected, including self-reported pain intensity using PAINReportIt

Identifiants

pubmed: 35285297
doi: 10.1177/15353702221080716
pmc: PMC9554168
doi:

Substances chimiques

Catechol O-Methyltransferase EC 2.1.1.6
COMT protein, human EC 2.1.1.6
DRD3 protein, human 0
Receptors, Dopamine D3 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1601-1608

Subventions

Organisme : NHLBI NIH HHS
ID : R13 HL106871
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049673
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL078536
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL153210
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA233444
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140031
Pays : United States

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Auteurs

Keesha L Powell-Roach (KL)

Department of Health Promotion and Disease Prevention, College of Nursing, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, Gainesville, FL 32603, USA.
Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL 32610, USA.

Yingwei Yao (Y)

Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, Gainesville, FL 32603, USA.

Margaret R Wallace (MR)

Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
University of Florida Genetics Institute, Gainesville, FL 32608, USA.

Srikar Chamala (S)

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

Yenisel Cruz-Almeida (Y)

Pain Research and Intervention Center of Excellence (PRICE), University of Florida, Gainesville, FL 32610, USA.
College of Dentistry, University of Florida, Gainesville, FL 32610, USA.

Ellie Jhun (E)

Clinical Development Team, OneOme, LLC, Minneapolis, MN 55413, USA.

Robert E Molokie (RE)

Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Jesse Brown VA Medical Center, Chicago, IL 60612, USA.

Zajie Jim Wang (ZJ)

Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL 60612, USA.

Diana J Wilkie (DJ)

Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, Gainesville, FL 32603, USA.

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Classifications MeSH