The Immunogenetics of Morphea and Lichen Sclerosus.
Immunogenetics
Lichen sclerosus
Morphea
Pathogenesis
Susceptibility genes
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
17
3
2022
Statut:
ppublish
Résumé
Morphea and lichen sclerosis et atrophicus (LSA) are two distinct immune-mediated diseases with a dominant presentation of dermal fibrosis and sclerosis. The two diseases have many similar clinical and histological features and tend to co-occur. Both diseases are thought to result from a derailment of the normal response to environmental triggers. Positive family history is more common in LSA than morphea but individuals with morphea have a higher frequency of concomitant and familial autoimmunity. These findings hint at the involvement of inheritance in susceptibility to LSA and morphea and thus provide a rationale for exploring the disease genetics. This chapter contains a comprehensive review of the pathogenesis of the two diseases and their known genetic associations including HLA class I and II genes.
Identifiants
pubmed: 35286696
doi: 10.1007/978-3-030-92616-8_7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155-172Informations de copyright
© 2022. Springer Nature Switzerland AG.
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