Arterial stiffness and left ventricular structure assessed by cardiac computed tomography in a multiethnic population.
Journal
Journal of cardiovascular medicine (Hagerstown, Md.)
ISSN: 1558-2035
Titre abrégé: J Cardiovasc Med (Hagerstown)
Pays: United States
ID NLM: 101259752
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
entrez:
14
3
2022
pubmed:
15
3
2022
medline:
28
4
2022
Statut:
ppublish
Résumé
Arterial stiffness expressed by cardio-ankle vascular index (CAVI) is a marker of arteriosclerosis. It can increase vascular load, which in turn may affect the viscoelastic myocardial properties and the left ventricular compliance. In the present study, we sought to investigate the association between CAVI and left ventricular structure assessed by cardiac computed tomography (CT) in a multiethnic adult cohort. CAVI was measured using the vascular screening system VaSera VS-1500 AU (Fukuda Denshi, Japan). The average of right and left CAVI values was utilized for the analysis. Left ventricular mass and volume were computed on mid-diastolic cardiac CTA images and indexed to body surface area (BSA) to obtain left ventricular mass index (LVMI) and left ventricular volume index (LVVI). The association between CAVI, LVMI and LVVI was assessed by multiple linear regression analysis. The study cohort was composed of 255 individuals (mean age 56.2 ± 13.4, 66% men). An abnormal CAVI value was defined as at least 8. One hundred and seventy-one individuals had CAVI values at least 8: they were older (P < 0.0001), more affected by of hypertension (P < 0.0001), dyslipidaemia (P = 0.0002), diabetes mellitus (P < 0.0001), previous history of myocardial infarction (P = 0.0246) or angioplasty (P = 0.0143), had higher CAC score (P < 0.0001) and prevalence of obstructive coronary artery disease (P = 0.001). When analysing CT-derived left ventricular geometry parameters, we found that individuals with abnormal CAVI had significantly smaller LVVI (P < 0.0001). This association remained valid after adjustments for age, sex, ethnicity (P = 0.0002), hypertension, dyslipidaemia, CAC score (P = 0.0004) and diabetes mellitus (P = 0.0034). The association between abnormal CAVI and LVMI was not significant in the unadjusted model (P = 0.593). Reduced vascular distensibility in an adult multiethnic population is associated with smaller LVVI beyond traditional cardiovascular risk factors suggesting that impaired left ventricular compliance mainly parallels increased arterial stiffness.
Sections du résumé
BACKGROUND
Arterial stiffness expressed by cardio-ankle vascular index (CAVI) is a marker of arteriosclerosis. It can increase vascular load, which in turn may affect the viscoelastic myocardial properties and the left ventricular compliance. In the present study, we sought to investigate the association between CAVI and left ventricular structure assessed by cardiac computed tomography (CT) in a multiethnic adult cohort.
METHODS
CAVI was measured using the vascular screening system VaSera VS-1500 AU (Fukuda Denshi, Japan). The average of right and left CAVI values was utilized for the analysis. Left ventricular mass and volume were computed on mid-diastolic cardiac CTA images and indexed to body surface area (BSA) to obtain left ventricular mass index (LVMI) and left ventricular volume index (LVVI). The association between CAVI, LVMI and LVVI was assessed by multiple linear regression analysis.
RESULTS
The study cohort was composed of 255 individuals (mean age 56.2 ± 13.4, 66% men). An abnormal CAVI value was defined as at least 8. One hundred and seventy-one individuals had CAVI values at least 8: they were older (P < 0.0001), more affected by of hypertension (P < 0.0001), dyslipidaemia (P = 0.0002), diabetes mellitus (P < 0.0001), previous history of myocardial infarction (P = 0.0246) or angioplasty (P = 0.0143), had higher CAC score (P < 0.0001) and prevalence of obstructive coronary artery disease (P = 0.001). When analysing CT-derived left ventricular geometry parameters, we found that individuals with abnormal CAVI had significantly smaller LVVI (P < 0.0001). This association remained valid after adjustments for age, sex, ethnicity (P = 0.0002), hypertension, dyslipidaemia, CAC score (P = 0.0004) and diabetes mellitus (P = 0.0034). The association between abnormal CAVI and LVMI was not significant in the unadjusted model (P = 0.593).
CONCLUSION
Reduced vascular distensibility in an adult multiethnic population is associated with smaller LVVI beyond traditional cardiovascular risk factors suggesting that impaired left ventricular compliance mainly parallels increased arterial stiffness.
Identifiants
pubmed: 35287157
doi: 10.2459/JCM.0000000000001272
pii: 01244665-202204000-00003
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-233Informations de copyright
Copyright © 2022 Italian Federation of Cardiology - I.F.C. All rights reserved.
Références
Miyoshi T, Doi M, Hirohata S, Sakane K, Kamikawa S, Kitawaki T, Kusachi S. Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with ischschemic heart disease. J Atheroscler Thromb 2010; 17:249–258.
Nakamura K, Tomaru T, Yamamura S, Miyashita Y, Shirai K, Noike H. Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis. Circ J 2007; 72:598–604.
Park JB, Park HE, Choi SY, Kim MK, Oh HB. Relation between cardio-ankle vascular index and coronary artery calcification or stenosis in asymptomatic subjects. J Atheroscler Thromb 2013; 20:557–567.
Hu H, Cui H, Han W, et al. A cutoff point for arterial stiffness using the cardio-ankle vascular index based on carotid arteriosclerosis. Hypertens Res 2013; 36:334–341.
Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter and cardio-ankle vascular index (CAVI). J Atherosclerosis Thromb 2006; 13:101–107.
Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness. Hypertens Res 2008; 31:1347–1355.
Takaki A, Ogawa H, Wakeyama T, et al. Cardio-ankle vascular index is a new noninvasive parameter of arterial stiffness. Circ J 2007; 71:1710–1714.
Kubozono T, Miyata M, Ueyama K, et al. Acute and chronic effects of smoking on arterial stiffness. Circ J 2011; 75:698–702.
Satoh N, Shimatsu A, Kato Y, et al. Evaluation of the cardio-ankle vascular index, a new indicator of arterial stiffness independent of blood pressure, in obesity and metabolic syndrome. Hypertens Res 2008; 31:1921–1930.
Namekata T, Suzuki K, Ishizuka N, Shirai K. Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study. BMC Cardiovasc Disord 2011; 11:51.
Birudaraju D, Cherukuri L, Kinninger A, et al. Relationship between cardio-ankle vascular index and obstructive coronary artery disease. Coron Artery Dis 2020; 31:550–555.
Izuhara M, Shioji K, Kadota S, et al. Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis. Circ J 2008; 72:1762–1767.
Kadota K, Takamura N, Aoyagi K, et al. Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis. Circ J 2008; 72:304–308.
Sakane K, Miyoshi T, Doi M, et al. Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function. J Atheroscler Thromb 2008; 15:261–268.
Namba T, Masaki N, Matsuo Y, et al. Arterial stiffness is significantly associated with left ventricular diastolic dysfunction in patients with cardiovascular disease. Int Heart J 2016; 57:729–735.
Osawa K, Nakanishi R, Miyoshi T, et al. Correlation of arterial stiffness with left atrial volume index and left ventricular mass index in young adults: evaluation by coronary computed tomography. Heart Lung Circ 2019; 28:932–938.
Mao SS, Li D, Vembar M, et al. Model-based automatic segmentation algorithm accurately assesses the whole cardiac volumetric parameters in patients with cardiac CT angiography: a validation study for evaluating the accuracy of the workstation software and establishing the reference values. Acad Radiol 2014; 21:639–647.
Klein R, Ametepe ES, Yam Y, Dwivedi G, Chow JB. Cardiac CT assessment of left ventricular mass in mid-diastasis and its prognostic value. Eur Heart J Cardiovasc Imaging 2017; 18:95–102.
Mosteller RD. Simplified calculation of body-surface area. New Engl J Med 1987; 317:1098–11098.
Leipsic J, Abbara S, Achenbach S, et al. SCCT guidelines for the interpretation and reporting of coronary CT angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee. J Cardiovasc Comput Tomogr 2014; 8:342–358.
Walker JR, Abadi S, Solomonica A, et al. Left-sided cardiac chamber evaluation using single-phase mid-diastolic coronary computed tomography angiography: derivation of normal values and comparison with conventional end-diastolic and end-systolic phases. Eur Radiol 2016; 26:3626–3634.
Avolio AP, Deng FQ, Li WQ, et al. Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 1985; 71:202–210.
Namekata T, Shirai K, Tanabe N, et al. Estimating the extent of subclinical arteriosclerosis of persons with prediabetes and diabetes mellitus among Japanese urban workers and their families: a cross-sectional study. BMC Cardiovasc Disord 2016; 16:52.
Salvetti M, Paini A, Facchetti R, et al. Relationship between vascular damage and left ventricular concentric geometry in patients undergoing coronary angiography: a multicenter prospective study. J Hypertens 2019; 37:1183–1190.