C1q+ macrophages: passengers or drivers of cancer progression.
C1q
T cell exhaustion
complement system
tumor-associated macrophages
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
20
09
2021
revised:
16
02
2022
accepted:
17
02
2022
pubmed:
16
3
2022
medline:
25
6
2022
entrez:
15
3
2022
Statut:
ppublish
Résumé
The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood. C1q is co-expressed in healthy and tumor macrophages with human leukocyte antigen DR (HLA-DR), Apolipoprotein E (APOE), and mannose receptor C-type 1 (MRC1) (CD206), suggesting a resident origin of this population. TAM expressing C1q correlate with T cell exhaustion and poor prognosis in numerous cancers. Herein, we discuss the plural roles of C1q in these macrophages and how it could drive cancer progression.
Identifiants
pubmed: 35288093
pii: S2405-8033(22)00042-5
doi: 10.1016/j.trecan.2022.02.006
pii:
doi:
Substances chimiques
Complement C1q
80295-33-6
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
517-526Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.