E.Co.Tech-electrochemical handheld breathalyzer COVID sensing technology.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 03 2022
14 03 2022
Historique:
received:
13
12
2021
accepted:
07
03
2022
entrez:
15
3
2022
pubmed:
16
3
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Breathomics is widely emerging as a strategy for non-invasive diagnosis of respiratory inflammation. In this study, we have evaluated the metabolic signals associated with Coronavirus (SARS COV-2), mainly the release of nitric oxide in breath. We have demonstrated the utility of a breath analyzer-based sensor platform for the detection of trace amounts of this target species. The sensor surface is modified with Room Temperature Ionic Liquid (RTIL) that allows faster diffusion of the target gas and can be used for gas sensing application. A low limit of detection (LOD) of 50 parts per billion has been achieved with a 95% confidence interval for detection of nitric oxide.. This inhouse designed sensor is incorporated into a breath analyzer system that displays enhanced sensitivity, specificity, linearity, and reproducibility for NO gas monitoring. The developed sensor platform can detect target concentrations of NO ranging from 50 to 250 ppb, using 1-Ethyl-3-methylimidazolium Tetrafluoroborate ([EMIM]BF
Identifiants
pubmed: 35288614
doi: 10.1038/s41598-022-08321-x
pii: 10.1038/s41598-022-08321-x
pmc: PMC8919908
doi:
Substances chimiques
Ionic Liquids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4370Subventions
Organisme : NHLBI NIH HHS
ID : U54 HL143541
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Biosens Bioelectron. 2021 Jan 1;171:112686
pubmed: 33086175
Lab Chip. 2012 Jan 7;12(1):153-8
pubmed: 22076475
Thromb Haemost. 2015 Mar;113(3):617-24
pubmed: 25392853
Biosens Bioelectron. 2019 Mar 1;128:122-128
pubmed: 30641454
Nat Biotechnol. 2021 Feb;39(2):144-147
pubmed: 33462510
Sci Rep. 2020 Feb 13;10(1):2557
pubmed: 32054949
ACS Nano. 2020 Apr 28;14(4):5135-5142
pubmed: 32293168
Phys Chem Chem Phys. 2015 Oct 28;17(40):26790-6
pubmed: 26394898
Int J Cardiol. 2013 Apr 30;165(1):184-92
pubmed: 22336250
Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1627-33
pubmed: 18556569
Clin Chem. 2003 Jun;49(6 Pt 1):953-5
pubmed: 12765993
ACS Sens. 2021 Apr 23;6(4):1408-1417
pubmed: 33825440
J Breath Res. 2020 Jul 21;14(4):042001
pubmed: 32599571
J Xray Sci Technol. 2021;29(1):19-36
pubmed: 33459685
J Clin Microbiol. 2020 May 26;58(6):
pubmed: 32245835
Expert Syst Appl. 2021 Oct 15;180:115141
pubmed: 33967405
Chemosphere. 2022 Jan;287(Pt 2):132187
pubmed: 34509007
Thorax. 2006 Sep;61(9):817-27
pubmed: 16936238
Redox Biol. 2020 Sep;36:101655
pubmed: 32738789
Nanomicro Lett. 2021;13(1):18
pubmed: 33163530
J Hazard Mater. 2022 Feb 5;423(Pt A):127058
pubmed: 34488091
Lancet. 2003 May 24;361(9371):1767-72
pubmed: 12781535
Lancet Respir Med. 2021 Jun;9(6):562-564
pubmed: 33887248
Chemosphere. 2022 Mar;291(Pt 3):132928
pubmed: 34800513
Sci Rep. 2017 Apr 4;7(1):642
pubmed: 28377578
Sensors (Basel). 2020 Feb 19;20(4):
pubmed: 32092938
Environ Res. 2022 Mar;204(Pt B):112082
pubmed: 34555403
Chembiochem. 2021 Apr 6;22(7):1176-1189
pubmed: 33119960
Biosens Bioelectron. 2021 Apr 1;177:112940
pubmed: 33444897
ACS Appl Mater Interfaces. 2021 Apr 14;13(14):16155-16165
pubmed: 33792285