MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice.

E-I balance inhibitory synapse interneuron microRNA mouse neuroscience schizophrenia short-term memory

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
15 03 2022
Historique:
received: 20 09 2021
accepted: 13 03 2022
pubmed: 16 3 2022
medline: 5 4 2022
entrez: 15 3 2022
Statut: epublish

Résumé

The proper development and function of neuronal circuits rely on a tightly regulated balance between excitatory and inhibitory (E/I) synaptic transmission, and disrupting this balance can cause neurodevelopmental disorders, for example, schizophrenia. MicroRNA-dependent gene regulation in pyramidal neurons is important for excitatory synaptic function and cognition, but its role in inhibitory interneurons is poorly understood. Here, we identify

Identifiants

pubmed: 35290180
doi: 10.7554/eLife.74056
pii: 74056
pmc: PMC8963876
doi:
pii:

Substances chimiques

MicroRNAs 0
Parvalbumins 0

Banques de données

GEO
['GSE173982']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2022, Daswani et al.

Déclaration de conflit d'intérêts

RD, CG, MS, PN, KW, SB, RF, CD, PG, JW, GS No competing interests declared

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Auteurs

Reetu Daswani (R)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Carlotta Gilardi (C)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Michael Soutschek (M)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Prakruti Nanda (P)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Kerstin Weiss (K)

Institute for Physiological Chemistry, Biochemical-Pharmacological Center Marburg, Philipps-University of Marburg, Marburg, Germany.

Silvia Bicker (S)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Roberto Fiore (R)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Christoph Dieterich (C)

Section of Bioinformatics and Systems Cardiology, Department of Internal Medicine III and Klaus Tschira Institute for Integrative Computational Cardiology, University of Heidelberg, Heidelberg, Germany.

Pierre-Luc Germain (PL)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Jochen Winterer (J)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

Gerhard Schratt (G)

Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zurich, Switzerland.

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Classifications MeSH