Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study.
Blood volume
Brain
Children
Dynamic susceptibility-contrast magnetic resonance imaging
Leakage correction
Magnetic resonance imaging
Multicenter
Perfusion
Tumor
Journal
Pediatric radiology
ISSN: 1432-1998
Titre abrégé: Pediatr Radiol
Pays: Germany
ID NLM: 0365332
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
29
10
2020
accepted:
11
12
2021
revised:
31
08
2021
pubmed:
16
3
2022
medline:
18
5
2022
entrez:
15
3
2022
Statut:
ppublish
Résumé
Relative cerebral blood volume (rCBV) measured using dynamic susceptibility-contrast MRI can differentiate between low- and high-grade pediatric brain tumors. Multicenter studies are required for translation into clinical practice. We compared leakage-corrected dynamic susceptibility-contrast MRI perfusion parameters acquired at multiple centers in low- and high-grade pediatric brain tumors. Eighty-five pediatric patients underwent pre-treatment dynamic susceptibility-contrast MRI scans at four centers. MRI protocols were variable. We analyzed data using the Boxerman leakage-correction method producing pixel-by-pixel estimates of leakage-uncorrected (rCBV Forty tumors were classified as low grade, 45 as high grade. Mean whole-tumor median rCBV Dynamic susceptibility-contrast MRI acquired at multiple centers helped distinguish between children's brain tumors. Relative cerebral blood volume was significantly higher in high-grade compared to low-grade tumors and differed among common tumor types. Vessel leakage correction is required to provide accurate rCBV, particularly in low-grade enhancing tumors.
Sections du résumé
BACKGROUND
Relative cerebral blood volume (rCBV) measured using dynamic susceptibility-contrast MRI can differentiate between low- and high-grade pediatric brain tumors. Multicenter studies are required for translation into clinical practice.
OBJECTIVE
We compared leakage-corrected dynamic susceptibility-contrast MRI perfusion parameters acquired at multiple centers in low- and high-grade pediatric brain tumors.
MATERIALS AND METHODS
Eighty-five pediatric patients underwent pre-treatment dynamic susceptibility-contrast MRI scans at four centers. MRI protocols were variable. We analyzed data using the Boxerman leakage-correction method producing pixel-by-pixel estimates of leakage-uncorrected (rCBV
RESULTS
Forty tumors were classified as low grade, 45 as high grade. Mean whole-tumor median rCBV
CONCLUSION
Dynamic susceptibility-contrast MRI acquired at multiple centers helped distinguish between children's brain tumors. Relative cerebral blood volume was significantly higher in high-grade compared to low-grade tumors and differed among common tumor types. Vessel leakage correction is required to provide accurate rCBV, particularly in low-grade enhancing tumors.
Identifiants
pubmed: 35290489
doi: 10.1007/s00247-021-05266-7
pii: 10.1007/s00247-021-05266-7
pmc: PMC9107460
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1134-1149Subventions
Organisme : Cancer Research UK
ID : C8232/A25261
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR-RP-R2-12-019
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C7809/A10342
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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