Cognitive impairment and microvascular function in end-stage renal disease.
cerebral small vessel disease
cognitive impairment
dialysis
retinal vessels
Journal
International journal of methods in psychiatric research
ISSN: 1557-0657
Titre abrégé: Int J Methods Psychiatr Res
Pays: United States
ID NLM: 9111433
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
13
10
2021
accepted:
01
03
2022
pubmed:
16
3
2022
medline:
7
6
2022
entrez:
15
3
2022
Statut:
ppublish
Résumé
Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.
Identifiants
pubmed: 35290686
doi: 10.1002/mpr.1909
pmc: PMC9159686
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1909Informations de copyright
© 2022 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.
Références
Kidney Int. 2018 Jan;93(1):221-230
pubmed: 28941940
J Am Soc Nephrol. 2017 Dec;28(12):3461-3472
pubmed: 28904002
Circulation. 2016 Nov 1;134(18):1328-1338
pubmed: 27682886
J Alzheimers Dis. 2018;62(3):1417-1441
pubmed: 29562536
Dement Geriatr Cogn Disord. 2014;38(1-2):31-8
pubmed: 24556891
Circulation. 2016 Nov 1;134(18):1339-1352
pubmed: 27678264
Blood Press. 2012 Jun;21(3):191-6
pubmed: 22263560
Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20
pubmed: 27793855
Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H631-6
pubmed: 12750062
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Invest Ophthalmol Vis Sci. 2004 May;45(5):1486-92
pubmed: 15111606
J Alzheimers Dis. 2015;50(3):699-707
pubmed: 26757037
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1484-7
pubmed: 16339339
Neurology. 2013 Jan 29;80(5):471-80
pubmed: 23303848
Clin Nephrol. 2000 Jun;53(6):445-51
pubmed: 10879664
Nephron. 2001 Sep;89(1):31-6
pubmed: 11528229
J Cereb Blood Flow Metab. 2013 Nov;33(11):1685-95
pubmed: 23963372
Clin J Am Soc Nephrol. 2010 Aug;5(8):1429-38
pubmed: 20576825
Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1698-708
pubmed: 24097425
BMC Nephrol. 2017 Jul 5;18(1):213
pubmed: 28676035
N Engl J Med. 2009 Oct 15;361(16):1539-47
pubmed: 19828531
Circ J. 2016 Jun 24;80(7):1499-503
pubmed: 27238834
PLoS One. 2014 Oct 27;9(10):e106700
pubmed: 25347578
Neurobiol Aging. 2014 Feb;35(2):373-7
pubmed: 24054993
Diabetes Care. 2008 Mar;31(3):544-9
pubmed: 18070990
Am J Kidney Dis. 2013 Feb;61(2):271-8
pubmed: 23040011
Exp Eye Res. 2015 Mar;132:240-8
pubmed: 25662314
Invest Ophthalmol Vis Sci. 2004 Sep;45(9):2949-54
pubmed: 15326106
PLoS One. 2017 Oct 10;12(10):e0184589
pubmed: 29016605
Am J Kidney Dis. 2016 Jun;67(6):925-35
pubmed: 26919914
Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1624-39
pubmed: 27342598
Am J Kidney Dis. 2017 Jun;69(6):780-787
pubmed: 28131531
Cardiovasc Res. 2022 Jan 29;118(2):612-621
pubmed: 33576412
Neurology. 2006 Jul 25;67(2):216-23
pubmed: 16864811
Microcirculation. 2013 Apr;20(3):257-68
pubmed: 23151190
Neuroimage. 2014 Jan 15;85 Pt 1:592-607
pubmed: 23664952
Microvasc Res. 2011 Jan;81(1):123-8
pubmed: 21094174
Am J Kidney Dis. 2019 Dec;74(6):782-790
pubmed: 31378643
Eur Heart J. 2018 Jan 1;39(1):47-56
pubmed: 29069316
BMC Nephrol. 2016 Oct 26;17(1):161
pubmed: 27784272
Circ Res. 2016 Feb 19;118(4):620-36
pubmed: 26892962
PLoS One. 2015 Dec 03;10(12):e0143706
pubmed: 26632813
Sci Rep. 2017 Oct 10;7(1):12906
pubmed: 29018233
Neuroscience. 1995 Dec;69(4):1195-204
pubmed: 8848107