Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis.

Aged Alzheimer Disease / diagnostic imaging Amyloid Amyloid beta-Peptides Amyloidosis Apolipoprotein E4 / genetics Female Humans Magnetic Resonance Imaging Male Positron-Emission Tomography

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
26 04 2022
Historique:
received: 26 05 2021
accepted: 18 01 2022
pubmed: 17 3 2022
medline: 28 4 2022
entrez: 16 3 2022
Statut: ppublish

Résumé

β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage Inference (SuStaIn) model to amyloid-PET data. Amyloid-PET data of 3,010 participants were pooled from 6 cohorts (ALFA+, EMIF-AD, ABIDE, OASIS, and ADNI). Standardized uptake value ratios were calculated for 17 regions. We applied the SuStaIn algorithm to identify consistent subtypes in the pooled dataset based on the cross-validation information criterion and the most probable subtype/stage classification per scan. The effects of demographics and risk factors on subtype assignment were assessed using multinomial logistic regression. Participants were mostly cognitively unimpaired (n = 1890 [62.8%]), had a mean age of 68.72 (SD 9.1) years, 42.1% were Whereas a 1-trajectory model recovers the established pattern of amyloid accumulation, SuStaIn determined that 3 subtypes were optimal, showing distinct associations with Alzheimer disease risk factors. Further analyses to determine clinical utility are warranted.

Sections du résumé

BACKGROUND AND OBJECTIVES
β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage Inference (SuStaIn) model to amyloid-PET data.
METHODS
Amyloid-PET data of 3,010 participants were pooled from 6 cohorts (ALFA+, EMIF-AD, ABIDE, OASIS, and ADNI). Standardized uptake value ratios were calculated for 17 regions. We applied the SuStaIn algorithm to identify consistent subtypes in the pooled dataset based on the cross-validation information criterion and the most probable subtype/stage classification per scan. The effects of demographics and risk factors on subtype assignment were assessed using multinomial logistic regression.
RESULTS
Participants were mostly cognitively unimpaired (n = 1890 [62.8%]), had a mean age of 68.72 (SD 9.1) years, 42.1% were
DISCUSSION
Whereas a 1-trajectory model recovers the established pattern of amyloid accumulation, SuStaIn determined that 3 subtypes were optimal, showing distinct associations with Alzheimer disease risk factors. Further analyses to determine clinical utility are warranted.

Identifiants

DOI: 10.1212/WNL.0000000000200148 PMID: 35292558 PMC: PMC9071373
pubmed: 35292558
pii: WNL.0000000000200148
doi: 10.1212/WNL.0000000000200148
pmc: PMC9071373
doi:

Substances chimiques

Amyloid 0
Amyloid beta-Peptides 0
Apolipoprotein E4 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1692-e1703

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Lyduine E Collij (LE)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Gemma Salvadó (G)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Viktor Wottschel (V)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0002-2902-2268

Sophie E Mastenbroek (SE)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Pierre Schoenmakers (P)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Fiona Heeman (F)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0001-7769-8329

Leon Aksman (L)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Alle Meije Wink (AM)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0002-8197-0118

Bart N M Berckel (BNM)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Wiesje M van de Flier (WM)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0001-8766-6224

Philip Scheltens (P)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0002-1046-6408

Pieter Jelle Visser (PJ)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0001-8008-9727

Frederik Barkhof (F)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0003-3543-3706

Sven Haller (S)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

Juan Domingo Gispert (JD)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.
ORCID: 0000-0002-6155-0642

Isadora Lopes Alves (I)

From the Department of Radiology and Nuclear Medicine (L.E.C., V.W., S.E.M., P.S., F.H., A.M.W., B.N.M.B., F.B., I.L.A.), Alzheimer Center and Department of Neurology (W.M.v.d.F., P.S., P.J.V.), and Department of Epidemiology & Data Science (W.M.v.d.F.), Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands; Barcelonaβeta Brain Research Center (BBRC) (G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (G.S., J.D.G.), Barcelona, Spain; Stevens Neuroimaging and Informatics Institute (L.A.), Keck School of Medicine, University of Southern California, Los Angeles; Centre for Medical Image Computing and Queen Square Institute of Neurology (F.B.), UCL, UK; Faculty of Medicine of the University of Geneva (S.H.); CIMC-Centre d'Imagerie Médicale de Cornavin (S.H.), Genève, Switzerland; Department of Surgical Sciences, Radiology (S.H.), Uppsala University, Sweden; Department of Radiology (S.H.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China; and Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) (J.D.G.), Madrid, Spain.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Spatial-Temporal Patterns of β-Amyloid...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Spatial-Temporal Patterns of β-Amyloid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Spatial-Temporal Patterns of β-Amyloid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Spatial-Temporal Patterns of β-Amyloid...
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