DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes: A new window into cognitive aging.
PET
aging
cognition
connectome
dopamine
lifespan
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
18
01
2022
received:
01
03
2021
accepted:
16
02
2022
pubmed:
17
3
2022
medline:
23
4
2022
entrez:
16
3
2022
Statut:
ppublish
Résumé
Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a multimodal, prospective 5-year longitudinal study spanning the adult human lifespan. DyNAMiC examines age-related changes in the brain's structural and functional connectome in relation to changes in dopamine D1 receptor availability (D1DR), and their associations to cognitive decline. Critically, due to the complete lack of longitudinal D1DR data, the true trajectory of one of the most age-sensitive dopamine systems remains unknown. The first DyNAMiC wave included 180 healthy participants (20-80 years). Brain imaging included magnetic resonance imaging assessing brain structure (white matter, gray matter, iron), perfusion, and function (during rest and task), and positron emission tomography (PET) with the [
Identifiants
pubmed: 35293013
doi: 10.1002/jnr.25039
pmc: PMC9313590
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1296-1320Informations de copyright
© 2022 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC.
Références
J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9
pubmed: 17519979
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40
pubmed: 19188601
Hum Brain Mapp. 2009 Oct;30(10):3127-41
pubmed: 19235882
J Intern Med. 2017 Jan;281(1):65-74
pubmed: 27453565
Mol Psychiatry. 2020 Jan;25(1):230-239
pubmed: 29743583
Neuroimage. 2019 Jan 15;185:335-348
pubmed: 30332613
Sci Adv. 2016 Jun 03;2(6):e1501672
pubmed: 27386561
Annu Rev Psychol. 2019 Jan 4;70:219-243
pubmed: 29949727
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Memory. 2003 May;11(3):261-75
pubmed: 12908675
Brain Struct Funct. 2019 Nov;224(8):2871-2882
pubmed: 31444615
Neuroimage. 2008 Jan 15;39(2):555-65
pubmed: 17962043
Brain Res. 2015 Jul 1;1612:83-103
pubmed: 25239478
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7918-23
pubmed: 27339132
J Neurosci. 1997 Nov 1;17(21):8528-35
pubmed: 9334425
Brain Struct Funct. 2009 Oct;213(6):525-33
pubmed: 19565262
J Neurosci Res. 2022 Jun;100(6):1296-1320
pubmed: 35293013
Brain Struct Funct. 2016 Nov;221(8):3891-3901
pubmed: 26498330
Neurobiol Aging. 2015 Dec;36(12):3255-3268
pubmed: 26363813
Cereb Cortex. 2013 Jul;23(7):1509-16
pubmed: 22645252
Behav Res Ther. 1990;28(6):487-95
pubmed: 2076086
Brain Connect. 2020 Jun;10(5):202-211
pubmed: 32308015
Front Mol Neurosci. 2019 Sep 25;12:229
pubmed: 31680849
Neuroimage. 2010 Apr 15;50(3):1303-12
pubmed: 20079855
Neuroimage. 2011 Jul 1;57(1):101-112
pubmed: 21515386
Cereb Cortex. 2008 Aug;18(8):1856-64
pubmed: 18063564
Neurobiol Aging. 2017 Sep;57:36-46
pubmed: 28599217
Brain Struct Funct. 2021 Apr;226(3):743-758
pubmed: 33423111
Cereb Cortex. 2009 Jan;19(1):72-8
pubmed: 18403396
Front Neurosci. 2008 Dec 15;2(2):234-44
pubmed: 19225597
Hum Brain Mapp. 2017 Jan;38(1):561-573
pubmed: 27654880
Neuropsychol Rev. 2009 Dec;19(4):415-35
pubmed: 19705281
Neuroimage. 2014 Nov 15;102 Pt 2:345-57
pubmed: 25109530
Neuron. 2015 Oct 7;88(1):207-19
pubmed: 26447582
Nat Neurosci. 2019 Feb;22(2):289-296
pubmed: 30664771
Nat Rev Neurol. 2010 Jan;6(1):15-28
pubmed: 20057496
Neuroimage. 2013 Nov 15;82:208-25
pubmed: 23747457
Psychol Aging. 2005 Mar;20(1):3-18
pubmed: 15769210
Epidemiology. 2018 Jan;29(1):87-95
pubmed: 28926372
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
Trends Neurosci. 2004 Aug;27(8):489-95
pubmed: 15271497
Neurobiol Aging. 2020 Dec;96:68-78
pubmed: 32949903
Neurobiol Aging. 2011 Oct;32(10):1849-56
pubmed: 19962789
Hum Brain Mapp. 2021 Feb 15;42(3):555-566
pubmed: 33079453
Neuroimage. 2018 Nov 1;181:605-616
pubmed: 30041059
Front Aging Neurosci. 2010 Jul 13;2:
pubmed: 20725526
Rev Neurosci. 2007;18(1):37-66
pubmed: 17405450
Neuroimage. 2010 Jun;51(2):910-7
pubmed: 20188183
Neuroimage. 2016 Jun;133:321-330
pubmed: 27001500
Neuroimage. 2020 Jul 1;214:116680
pubmed: 32105885
Trends Cogn Sci. 2015 Sep;19(9):506-14
pubmed: 26187033
Biol Psychiatry. 2011 Jun 15;69(12):e113-25
pubmed: 21531388
J Cereb Blood Flow Metab. 2003 Sep;23(9):1096-112
pubmed: 12973026
Neuropsychopharmacology. 1994 Dec;11(4):245-56
pubmed: 7531978
Brain Res Brain Res Rev. 2000 Mar;31(2-3):295-301
pubmed: 10719156
PLoS Comput Biol. 2005 Sep;1(4):e42
pubmed: 16201007
Prog Neurobiol. 2004 Sep;74(1):1-58
pubmed: 15381316
Magn Reson Med. 2000 Jul;44(1):162-7
pubmed: 10893535
Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22682-6
pubmed: 21156826
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6169-74
pubmed: 23530246
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
pubmed: 11209064
Cereb Cortex. 2005 Nov;15(11):1676-89
pubmed: 15703252
Trends Cogn Sci. 2012 May;16(5):292-305
pubmed: 22542563
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):771-778
pubmed: 31874926
Biochim Biophys Acta. 2012 Mar;1822(3):408-15
pubmed: 21930202
Am Psychol. 1994 Apr;49(4):304-13
pubmed: 8203802
Int J Public Health. 2013 Aug;58(4):637-42
pubmed: 23089674
Front Hum Neurosci. 2011 Mar 31;5:32
pubmed: 21503140
Neuroimage. 2016 May 15;132:334-343
pubmed: 26915497
J Int Neuropsychol Soc. 2012 Nov;18(6):1081-5
pubmed: 23158231
J Neurosci. 2011 Oct 5;31(40):14284-90
pubmed: 21976513
Hum Brain Mapp. 2019 Jul;40(10):3125-3138
pubmed: 30932295
Scand J Psychol. 2013 Dec;54(6):502-7
pubmed: 24118069
Neuroscience. 2014 Dec 12;282:248-57
pubmed: 25445194
Front Aging Neurosci. 2014 Sep 25;6:252
pubmed: 25309431
J Int Neuropsychol Soc. 2010 Sep;16(5):754-60
pubmed: 20673381
Nature. 2007 May 3;447(7140):83-6
pubmed: 17476267
Neurosci Biobehav Rev. 2010 Apr;34(5):625-30
pubmed: 20152855
Brain Struct Funct. 2019 Nov;224(8):2619-2630
pubmed: 31332515
J Hypertens. 2002 Jan;20(1):29-35
pubmed: 11791023
Cereb Cortex. 2019 Jan 1;29(1):397-409
pubmed: 30357316
Neuroimage. 2019 Oct 1;199:93-104
pubmed: 31141738
Psychol Aging. 2009 Mar;24(1):154-62
pubmed: 19290746
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
Dialogues Clin Neurosci. 2013 Sep;15(3):247-62
pubmed: 24174898
Neuroimage. 2016 May 1;131:133-41
pubmed: 26702778
Hum Brain Mapp. 2014 Jan;35(1):319-30
pubmed: 22915491
Neuroimage. 2007 Feb 15;34(4):1643-9
pubmed: 17174573
Biol Psychiatry. 2013 Sep 1;74(5):340-7
pubmed: 23290495
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Brain Res. 1990 Feb 5;508(2):349-52
pubmed: 2407314
Neuroimage. 2020 Feb 1;206:116232
pubmed: 31593794
J Neurosci. 2008 Nov 12;28(46):12032-8
pubmed: 19005068
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Neurosci Biobehav Rev. 2014 Sep;45:100-18
pubmed: 24875392
Nat Neurosci. 2015 Nov;18(11):1664-71
pubmed: 26457551
Trends Cogn Sci. 2012 Mar;16(3):181-8
pubmed: 22341211
Trends Cogn Sci. 2017 Jan;21(1):32-45
pubmed: 27865786
J Neurosci. 2013 May 15;33(20):8668-77
pubmed: 23678111
Neurobiol Aging. 2020 Dec;96:205-222
pubmed: 33038808
Neuroimage. 2017 Oct 15;160:32-40
pubmed: 28159687
Am J Psychiatry. 2000 Apr;157(4):635-7
pubmed: 10739428
Neurosci Biobehav Rev. 2013 Sep;37(8):1363-79
pubmed: 23707776
J Neurosci Methods. 2017 Jan 30;276:56-72
pubmed: 27832957
Neuroimage. 2004 Oct;23(2):724-38
pubmed: 15488422
Radiology. 1989 Aug;172(2):549-54
pubmed: 2748838
Neuroimage. 2021 Nov 15;242:118449
pubmed: 34358662
Neurosci Biobehav Rev. 2010 Apr;34(5):670-7
pubmed: 20026186
Nat Neurosci. 2014 May;17(5):652-60
pubmed: 24686784
Neuroimage. 1996 Dec;4(3 Pt 1):153-8
pubmed: 9345505
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Ann N Y Acad Sci. 2008 Mar;1124:1-38
pubmed: 18400922
J Am Geriatr Soc. 2012 Dec;60(12):2308-12
pubmed: 23110764
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21219-21227
pubmed: 31570622
Front Syst Neurosci. 2010 Jun 17;4:19
pubmed: 20592951
Front Med (Lausanne). 2019 Oct 04;6:204
pubmed: 31637242
J Hypertens. 2008 Dec;26(12):2295-302
pubmed: 19008708
Neurobiol Aging. 2017 Mar;51:167-176
pubmed: 28089351
Psychol Bull. 1994 Mar;115(2):163-96
pubmed: 8165269
J Neurosci. 2019 Jul 10;39(28):5534-5550
pubmed: 31109962
Nature. 2016 Aug 11;536(7615):171-178
pubmed: 27437579
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17654-9
pubmed: 25422457
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4997-5006
pubmed: 25368199
Hum Brain Mapp. 2009 Apr;30(4):1051-9
pubmed: 18412132
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946
Ageing Res Rev. 2020 Dec;64:101184
pubmed: 32992046
Cereb Cortex. 2016 Oct;26(10):3953-3963
pubmed: 27522073
Scand J Psychol. 2008 Feb;49(1):11-8
pubmed: 18190398
Neuron. 2007 Dec 6;56(5):924-35
pubmed: 18054866
Appl Neuropsychol Adult. 2020 Nov-Dec;27(6):497-503
pubmed: 30793954