Triazoloquinazoline derived classical DNA intercalators: Design, synthesis, in silico ADME profile, docking, and antiproliferative evaluations.
DNA intercalators
[1,2,4]triazolo[4,3-c]quinazoline
anticancer agents
molecular docking
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
20
02
2022
received:
21
12
2021
accepted:
22
02
2022
pubmed:
17
3
2022
medline:
3
6
2022
entrez:
16
3
2022
Statut:
ppublish
Résumé
Thirteen novel [1,2,4]triazolo[4,3-c]quinazoline derivatives as DNA intercalators were synthesized and their anticancer activities evaluated against HepG2 and HCT-116 cells. A docking study was carried out to explore how the new derivatives bind to active sites of DNA. The docking data were highly interrelated with that of biological testing. The HCT-116 cell line was the most sensitive one to the effect of the new derivatives. Compound 7
Identifiants
pubmed: 35293628
doi: 10.1002/ardp.202100506
doi:
Substances chimiques
Intercalating Agents
0
Quinazolines
0
Triazoles
0
triazoloquinazoline
0
Doxorubicin
80168379AG
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100506Informations de copyright
© 2022 Deutsche Pharmazeutische Gesellschaft.
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