Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants.
Alkynes
/ pharmacokinetics
Animals
Anti-Retroviral Agents
/ pharmacokinetics
CD4-Positive T-Lymphocytes
HIV Infections
/ drug therapy
HIV-1
/ genetics
Humans
Macaca mulatta
Oligopeptides
/ pharmacokinetics
Simian Acquired Immunodeficiency Syndrome
/ drug therapy
Simian Immunodeficiency Virus
Viral Load
Virus Latency
/ drug effects
Virus Replication
HIV
HIV cure
NHP
SIV
pediatric HIV
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
13 04 2022
13 04 2022
Historique:
pubmed:
17
3
2022
medline:
16
4
2022
entrez:
16
3
2022
Statut:
ppublish
Résumé
The "shock and kill" strategy for HIV-1 cure incorporates latency-reversing agents (LRA) in combination with interventions that aid the host immune system in clearing virally reactivated cells. LRAs have not yet been investigated in pediatric clinical or preclinical studies. Here, we evaluated an inhibitor of apoptosis protein (IAP) inhibitor (IAPi), AZD5582, that activates the noncanonical NF-κB (ncNF-κB) signaling pathway to reverse latency. Ten weekly doses of AZD5582 were intravenously administered at 0.1 mg/kg to rhesus macaque (RM) infants orally infected with SIV
Identifiants
pubmed: 35293766
doi: 10.1128/jvi.01699-21
pmc: PMC9006931
doi:
Substances chimiques
Alkynes
0
Anti-Retroviral Agents
0
N,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)
0
Oligopeptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0169921Subventions
Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA138292
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164567
Pays : United States
Organisme : NIH HHS
ID : S10 OD026799
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133706
Pays : United States
Organisme : NIH HHS
ID : U24 OD011023
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States
Organisme : NIH HHS
ID : U42 OD011023
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164566
Pays : United States
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