Spatial redistribution of neurosecretory vesicles upon stimulation accelerates their directed transport to the plasma membrane.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
06
2021
accepted:
11
02
2022
entrez:
16
3
2022
pubmed:
17
3
2022
medline:
26
4
2022
Statut:
epublish
Résumé
Through the integration of results from an imaging analysis of intracellular trafficking of labelled neurosecretory vesicles in chromaffin cells, we develop a Markov state model to describe their transport and binding kinetics. Our simulation results indicate that a spatial redistribution of neurosecretory vesicles occurs upon secretagogue stimulation leading vesicles to the plasma membrane where they undergo fusion thereby releasing adrenaline and noradrenaline. Furthermore, we find that this redistribution alone can explain the observed up-regulation of vesicle transport upon stimulation and its directional bias towards the plasma membrane. Parameter fitting indicates that in the deeper compartment within the cell, vesicle transport is asymmetric and characterised by a bias towards the plasma membrane.
Identifiants
pubmed: 35294476
doi: 10.1371/journal.pone.0264521
pii: PONE-D-21-20030
pmc: PMC8926195
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0264521Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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