Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES).

Atrophy / pathology Brain / diagnostic imaging Disease Progression Exercise Exercise Therapy Humans Magnetic Resonance Imaging / methods Multiple Sclerosis / diagnostic imaging Neoplasm Recurrence, Local / pathology
Multiple sclerosis early treatment exercise neuroprotection relapse rate

Journal

Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185

Informations de publication

Date de publication:
09 2022
Historique:
pubmed: 18 3 2022
medline: 27 7 2022
entrez: 17 3 2022
Statut: ppublish

Résumé

Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated 'window of opportunity' exists early in the disease course. To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes. This randomized controlled trial ( No between-group differences were observed for primary outcomes, relapse rate (incidence-rate-ratio exercise relative to control: (0.49 (0.15; 1.66), Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy, but does positively affect the microstructural integrity of important motor-related tracts and nuclei.

Sections du résumé

BACKGROUND
Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated 'window of opportunity' exists early in the disease course.
OBJECTIVE
To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes.
METHODS
This randomized controlled trial (
RESULTS
No between-group differences were observed for primary outcomes, relapse rate (incidence-rate-ratio exercise relative to control: (0.49 (0.15; 1.66),
CONCLUSION
Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy, but does positively affect the microstructural integrity of important motor-related tracts and nuclei.

Identifiants

DOI: 10.1177/13524585221079200 PMID: 35296183
pubmed: 35296183
doi: 10.1177/13524585221079200
doi:

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1620-1629

Auteurs

Morten Riemenschneider (M)

Exercise Biology, Department of Public Health, Aarhus University, Aarhus C, Denmark.
ORCID: 0000-0003-1903-0333

Lars G Hvid (LG)

Exercise Biology, Department of Public Health, Aarhus University, Aarhus C, Denmark/MS Hospitals in Denmark, The Danish MS Hospitals, Ry and Haslev, Denmark.
ORCID: 0000-0003-3233-0429

Steffen Ringgaard (S)

The MR Research Centre, Aarhus University Hospital, Aarhus N, Denmark.

Mikkel Karl Emil Nygaard (MKE)

Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark.
ORCID: 0000-0002-9450-7544

Simon Fristed Eskildsen (SF)

Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark.

Tobias Gaemelke (T)

Exercise Biology, Department of Public Health, Aarhus University, Aarhus C, Denmark.

Melinda Magyari (M)

The Danish Multiple Sclerosis Registry, Department of Neurology, University Hospital Rigshospitalet, Glostrup, Denmark.

Henrik Boye Jensen (HB)

Brain and Nerve Diseases, Lillebaelt Hospital, Kolding, Denmark/Department of Regional Health Research, University of Southern Denmark, Odense M, Denmark.

Helle Hvilsted Nielsen (HH)

Department of Neurology, Odense University Hospital, Odense C, Denmark.

Matthias Kant (M)

MS-Clinics of Southern Jutland (Sønderborg, Esbjerg and Kolding), Department of Neurology, Sønderborg, Denmark.

Masoud Falah (M)

MS-Clinic Hospital Unit of Western Denmark, Department of Neurology, Holstebro, Denmark.

Thor Petersen (T)

The Multiple Sclerosis Clinic, Department of Neurology, Aarhus University Hospital, Aarhus N, Denmark.

Egon Stenager (E)

Department of Regional Health Research, University of Southern Denmark, Odense M, Denmark/MS-Clinics of Southern Jutland (Sønderborg, Esbjerg and Kolding), Department of Neurology, Sønderborg, Denmark.

Ulrik Dalgas (U)

Exercise Biology, Department of Public Health, Aarhus University, Aarhus C, Denmark.
ORCID: 0000-0003-4132-2789

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Investigating the potential disease-modifying...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Investigating the potential disease-modifying...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Investigating the potential disease-modifying...
questionsmedicales.fr › Activités humaines › Exercice physique › Investigating the potential disease-modifying...
questionsmedicales.fr › Thérapeutique › Techniques de physiothérapie › Traitement par les exercices physiques › Investigating the potential disease-modifying...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Investigating the potential disease-modifying...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Investigating the potential disease-modifying...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Investigating the potential disease-modifying...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Investigating the potential disease-modifying...