Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
16 03 2022
16 03 2022
Historique:
received:
28
09
2021
accepted:
24
02
2022
revised:
21
02
2022
entrez:
17
3
2022
pubmed:
18
3
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Prior research has demonstrated high levels of cognitive and physical functional impairments in World Trade Center (WTC) responders. A follow-up neuroimaging study identified changes to white matter connectivity within the cerebellum in responders with cognitive impairment (CI). In the first study to examine cerebellar cortical thickness in WTC responders with CI, we fielded a structural magnetic resonance imaging protocol. WTC responders (N = 99) participated in a structural magnetic resonance imaging (MRI) study, of whom 48 had CI. Participants with CI did not differ demographically or by intracranial volume when compared to cognitively unimpaired participants. MRIs were processed using the CERES imaging pipeline; bilateral cortical thickness in 12 cerebellar lobules was reported. Analyses were completed comparing mean cerebellar cortical thickness across groups. Lobules were examined to determine the location and functional correlates of reduced cerebellar cortical thickness. Multivariable-adjusted analyses accounted for the false discovery rate. Mean cerebellar cortical thickness was reduced by 0.17 mm in responders with CI. Decrements in cerebellar cortical thickness were symmetric and located in the Cerebellar Crus (I and II), and in Lobules IV, VI, VIIb, VIIIa, VIIIb, and IX. Cerebellar cortical thickness was associated with episodic memory, response speed, and tandem balance. WTC responders with CI had evidence of reduced cerebellar cortical thickness that was present across lobules in a pattern unique to this cohort.
Identifiants
pubmed: 35296637
doi: 10.1038/s41398-022-01873-6
pii: 10.1038/s41398-022-01873-6
pmc: PMC8927406
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
107Subventions
Organisme : NIA NIH HHS
ID : R01 AG049953
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067590
Pays : United States
Organisme : NIOSH CDC HHS
ID : U01 OH011314
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066514
Pays : United States
Informations de copyright
© 2022. The Author(s).
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