Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 03 2022
16 03 2022
Historique:
received:
30
09
2021
accepted:
26
01
2022
entrez:
17
3
2022
pubmed:
18
3
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel disease, who are treated either with the anti-TNF antibody, infliximab, or with vedolizumab targeting a gut-specific anti-integrin that does not impair systemic immunity. Geometric mean [SD] anti-S RBD antibody concentrations are lower and half-lives shorter in patients treated with infliximab than vedolizumab, following two doses of BNT162b2 (566.7 U/mL [6.2] vs 4555.3 U/mL [5.4], p <0.0001; 26.8 days [95% CI 26.2 - 27.5] vs 47.6 days [45.5 - 49.8], p <0.0001); similar results are also observed with ChAdOx1 nCoV-19 vaccination (184.7 U/mL [5.0] vs 784.0 U/mL [3.5], p <0.0001; 35.9 days [34.9 - 36.8] vs 58.0 days [55.0 - 61.3], p value < 0.0001). One fifth of patients fail to mount a T cell response in both treatment groups. Breakthrough SARS-CoV-2 infections are more frequent (5.8% (201/3441) vs 3.9% (66/1682), p = 0.0039) in patients treated with infliximab than vedolizumab, and the risk of breakthrough SARS-CoV-2 infection is predicted by peak anti-S RBD antibody concentration after two vaccine doses. Irrespective of the treatments, higher, more sustained antibody levels are observed in patients with a history of SARS-CoV-2 infection prior to vaccination. Our results thus suggest that adapted vaccination schedules may be required to induce immunity in at-risk, anti-TNF-treated patients.
Identifiants
pubmed: 35296643
doi: 10.1038/s41467-022-28517-z
pii: 10.1038/s41467-022-28517-z
pmc: PMC8927425
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
COVID-19 Vaccines
0
Tumor Necrosis Factor Inhibitors
0
Viral Vaccines
0
vedolizumab
9RV78Q2002
ChAdOx1 nCoV-19
B5S3K2V0G8
Infliximab
B72HH48FLU
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1379Subventions
Organisme : Medical Research Council
ID : MC_PC_20060
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S034919/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019553/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R02622X/1
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001169
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W020610/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V036939/1
Pays : United Kingdom
Investigateurs
Klaartje B Kok
(KB)
Farjhana Bokth
(F)
Bessie Cipriano
(B)
Caroline Francia
(C)
Nosheen Khalid
(N)
Hafiza Khatun
(H)
Ashley Kingston
(A)
Irish Lee
(I)
Anouk Lehmann
(A)
Kinnari Naik
(K)
Elise Pabriaga
(E)
Nicolene Plaatjies
(N)
Kevin Samuels
(K)
Rebecca Saich
(R)
Hayley Cousins
(H)
Wendy Fraser
(W)
Rachel Thomas
(R)
Matthew Brown
(M)
Benjamin White
(B)
Nikolaos Kirkineziadis
(N)
Bernadette Tilley
(B)
Rafeeq Muhammed
(R)
Rehana Bi
(R)
Catherine Cotter
(C)
Jayne Grove
(J)
Kate Hong
(K)
Ruth Howman
(R)
Monica Mitchell
(M)
Sophie Clayton
(S)
Sugrah Sultan
(S)
Melanie Rooney
(M)
Charlotte Cottrill
(C)
Salil Singh
(S)
Chris Dawe
(C)
Robert Hull
(R)
Natalie Silva
(N)
Jonathan Manning
(J)
Lauren Finlayson
(L)
Allison Roebuck
(A)
Joy Dawson
(J)
Sunil Sonwalkar
(S)
Naomi Chambers
(N)
Matthew Robinson
(M)
Andrew Haigh
(A)
Lear Matapure
(L)
Tim Raine
(T)
Varun George
(V)
Christina Kapizioni
(C)
Konstantina Strongili
(K)
Tina Thompson
(T)
Mohamed Ahmed
(M)
Christos Kontos
(C)
Christophe Bourges
(C)
Isabella Barbutti
(I)
Megan E Gozzard
(ME)
Philip Hendy
(P)
Rhian Bull
(R)
Patricia Costa
(P)
Lisa Davey
(L)
Hayley Hannington
(H)
Kribashnie Nundlall
(K)
Catarina Martins
(C)
Laura Avanzi
(L)
Jaime Carungcong
(J)
Sabrina Barr
(S)
Richard Appleby
(R)
Emma Johnson
(E)
Kath Phillis
(K)
Rachel Gascoyne
(R)
Amanda Crowder
(A)
Amanda Whileman
(A)
Ian London
(I)
Jenny Grounds
(J)
Emmeline Martin
(E)
Susie Pajak
(S)
Jude Price
(J)
Kathryn Cawley
(K)
Anjan Dhar
(A)
Ellen Brown
(E)
Amanda Cowton
(A)
Kimberley Stamp
(K)
Ben Warner
(B)
Carmel Stuart
(C)
Louise Lacey
(L)
Shanika de Silva
(S)
Clare Allcock
(C)
Philip Harvey
(P)
Lesley Jones
(L)
Elise Cooke
(E)
Johanne Brooks
(J)
Pearl Baker
(P)
Hannah Beadle
(H)
Carina Cruz
(C)
Debbie Potter
(D)
Joe Collum
(J)
Farzana Masters
(F)
Aashish Kumar
(A)
Samantha Coetzee
(S)
Mihaela Peiu
(M)
Becky Icke
(B)
Meena Raj
(M)
Edward Gaynor
(E)
Sibongile Chadokufa
(S)
Bonita Huggett
(B)
Hamza Meghari
(H)
Sara El-Khouly
(S)
Fevronia Kiparissi
(F)
Waffa Girshab
(W)
Andrew Claridge
(A)
Emily Fowler
(E)
Laura McCafferty
(L)
Karolina Christodoulides
(K)
Angela Clifford
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Sailish Honap
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Samuel Lim
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Raphael Luber
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Parizade Raymode
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(N)
Senthuran Balachandran
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(N)
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Jagrul Miah
(J)
Lisa Canclini
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Melony Hayes
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Sally Myers
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Alison Talbot
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Silvia Zagalo
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(N)
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(R)
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Andrew Fagbemi
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Mark Mencias
(M)
Abigail Seaward
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Jessica Sousa
(J)
Nooria Said
(N)
Mark Soomaroo
(M)
Valentina Raspa
(V)
Asha Tacouri
(A)
Nicholas Reps
(N)
Rebecca Martin
(R)
Christian Selinger
(C)
Jenelyn Carbonell
(J)
Felicia Onovira
(F)
Doris Quartey
(D)
Alice L'Anson
(A)
Andrew Ashworth
(A)
Jessica Bailey
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Angie Dunn
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Ruth Habibi
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(R)
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Sharafaath Shariff
(S)
Aileen Fraser
(A)
Dwayne Punnette
(D)
Charlotte Bishop-Hurman
(C)
Elizabeth Undrell
(E)
Katherine Belfield
(K)
Said Din
(S)
Catherine Addleton
(C)
Marie Appleby
(M)
Johanna Brown
(J)
Kathleen Holding
(K)
Patricia Hooper
(P)
John deCaestecker
(J)
Olivia Watchorn
(O)
Chris Hayward
(C)
Susan Inniss
(S)
Lucy Pritchard
(L)
Karen Rudge
(K)
Amanda Carney
(A)
Jervoise Andreyev
(J)
Caroline Hayhurst
(C)
Carol Lockwood
(C)
Lynn Osborne
(L)
Amanda Roper
(A)
Karen Warner
(K)
Julia Hindle
(J)
Caroline Watt
(C)
Kinga Szymiczek
(K)
Shameer Mehta
(S)
James Bell
(J)
William Blad
(W)
Lisa Whitley
(L)
Durai Dhamaraj
(D)
Mark Baker
(M)
Elizabeth John Sivamurugan
(EJ)
Mim Evans
(M)
Fraser Cummings
(F)
Clare Harris
(C)
Amy Jones
(A)
Liga Krauze
(L)
Sohail Rahmany
(S)
Michelle Earl
(M)
Jenny Vowles
(J)
Audrey Torokwa
(A)
Mirela Petrova
(M)
Andrew Procter
(A)
Jo Stanley
(J)
Claudia Silvamoniz
(C)
Marion Bettey
(M)
Amar Wahid
(A)
Zoe Morrison
(Z)
Rhian Thomas-Turner
(R)
Louise Yendle
(L)
Jennifer Muller
(J)
Marcus Mitchell
(M)
John Kirkwood
(J)
Anna Barnes
(A)
Rakesh Chaudhary
(R)
Melanie Claridge
(M)
Chiara Ellis
(C)
Cheryl Kemp
(C)
Ogwa Tobi
(O)
Jentus Milton
(J)
Emma Johnston
(E)
Metod Oblak
(M)
Jo Godden
(J)
Charlie Lees
(C)
Debbie Alexander
(D)
Kate Covil
(K)
Lauranne Derikx
(L)
Sryros Siakavellas
(S)
Helen Baxter
(H)
Scott Robertson
(S)
Linda Smith
(L)
Beena Poulose
(B)
Anne Colemam
(A)
Margareta Balint
(M)
Gareth Rhys-Jones
(G)
Kerrie Johns
(K)
Rachel Hughes
(R)
Janet Phipps
(J)
Abigail Taylor
(A)
Catherine MacPhee
(C)
Suzanne Brooks
(S)
Katie Smith
(K)
Linda Howard
(L)
Dianne Wood
(D)
Ajay Muddu
(A)
Laura Barman
(L)
Janine Mallinson
(J)
Tania Neale
(T)
Diana Ionita
(D)
Kerry Elliot
(K)
Alison Turnball
(A)
Iola Thomas
(I)
Kelly Andrews
(K)
Jonathon Sutton
(J)
Caroline Mulvaney Jones
(CM)
Julia Roberts
(J)
Jeannie Bishop
(J)
Informations de copyright
© 2022. The Author(s).
Références
J Crohns Colitis. 2022 Mar 14;16(3):389-397
pubmed: 34473254
J Clin Microbiol. 2020 Sep 22;58(10):
pubmed: 32747400
Lancet. 2021 Jul 31;398(10298):385-387
pubmed: 34274038
Gastroenterology. 2021 Aug;161(2):715-718.e4
pubmed: 33887219
Science. 2021 Apr 30;:
pubmed: 33931567
N Engl J Med. 2021 Sep 23;385(13):1244-1246
pubmed: 34379917
Gut. 2021 May;70(5):865-875
pubmed: 33753421
Ann Rheum Dis. 2017 Sep;76(9):1559-1565
pubmed: 28468794
J Leukoc Biol. 2003 Aug;74(2):216-22
pubmed: 12885938
Sci Immunol. 2020 Dec 23;5(54):
pubmed: 33361161
J Biomed Inform. 2019 Jul;95:103208
pubmed: 31078660
BMJ. 2021 May 13;373:n1088
pubmed: 33985964
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Lancet. 2021 Jan 9;397(10269):99-111
pubmed: 33306989
Gastroenterology. 2022 Jan;162(1):88-108.e9
pubmed: 34599933
J Clin Invest. 1994 Aug;94(2):749-60
pubmed: 8040330
Inflamm Bowel Dis. 2021 Sep 16;:
pubmed: 34528661
N Engl J Med. 2021 Nov 4;385(19):1761-1773
pubmed: 34525277
N Engl J Med. 2013 Aug 22;369(8):711-21
pubmed: 23964933
J Exp Med. 1996 Oct 1;184(4):1397-411
pubmed: 8879212
Lancet. 2021 Dec 18;398(10318):2277-2287
pubmed: 34774197
NPJ Vaccines. 2021 May 13;6(1):74
pubmed: 33986272
Ann Rheum Dis. 2013 Jun;72(6):1037-43
pubmed: 22968102
Gastroenterology. 2021 Oct;161(4):1340-1343.e2
pubmed: 34144046
Gut. 2021 Oct;70(10):1884-1893
pubmed: 33903149
Lancet. 2021 Oct 23;398(10310):1482-1484
pubmed: 34619100
Immunology. 2007 Dec;122(4):551-61
pubmed: 17635614
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Nat Med. 2021 Sep;27(9):1525-1529
pubmed: 34262158
N Engl J Med. 2020 Dec 17;383(25):2439-2450
pubmed: 33053279