HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features.
Aged
Aged, 80 and over
Carcinoma in Situ
/ pathology
Cyclin-Dependent Kinase Inhibitor p16
/ metabolism
Humans
Male
Papillomaviridae
/ genetics
Papillomavirus Infections
/ pathology
Penile Neoplasms
/ pathology
Skin Neoplasms
/ pathology
Squamous Intraepithelial Lesions
/ pathology
Tumor Suppressor Protein p53
/ metabolism
Journal
The American journal of surgical pathology
ISSN: 1532-0979
Titre abrégé: Am J Surg Pathol
Pays: United States
ID NLM: 7707904
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
pubmed:
18
3
2022
medline:
20
7
2022
entrez:
17
3
2022
Statut:
ppublish
Résumé
Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. From 2000 to 2021, 55 surgical specimens of PSCC were identified. In all cases, thorough morphologic evaluation, HPV DNA detection, and p16, p53, and Ki-67 immunohistochemical (IHC) staining was performed. HPV-independent status was assigned based on both negative results for p16 IHC and HPV DNA. Thirty-six of the 55 PSCC (65%) were HPV-independent. An intraepithelial precursor was identified in 26/36 cases (72%). Five of them (19%) had basaloid features, morphologically indistinguishable from HPV-associated HSIL. The median age of the 5 patients was 74 years (range: 67 to 83 y). All 5 cases were p16 and DNA HPV-negative. Immunohistochemically, 3 cases showed an abnormal p53 pattern, and 2 showed wild-type p53 staining. The associated invasive carcinoma was basaloid in 4 cases and the usual (keratinizing) type in 1. In conclusion, a small proportion of HPV-independent PSCC may arise on adjacent intraepithelial lesions morphologically identical to HPV-associated HSIL. This unusual histologic pattern has not been previously characterized in detail in PSCC. p16 IHC is a valuable tool to identify these lesions and differentiate them from HPV-associated HSIL.
Identifiants
pubmed: 35297786
doi: 10.1097/PAS.0000000000001885
pii: 00000478-202208000-00007
pmc: PMC9281510
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p16
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1071-1077Informations de copyright
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
Conflicts of Interest and Source of Funding: Project “PI17/00772; “Valor de la detección del ARNm de los biomarcadores CDKN2A, MKi67, TOP2A en la prevención secundaria del cáncer de cuello de útero, funded by Instituto de Salud Carlos III and co-funded by the European Union (ERDF) “A way to make Europe”. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
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