Differentiating active from stable vitiligo: The role of dermoscopic findings and their relation to CXCL10.
CXCL10
VIDA
dermoscopy
vitiligo
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
revised:
11
12
2021
received:
04
10
2021
accepted:
08
03
2022
pubmed:
18
3
2022
medline:
3
11
2022
entrez:
17
3
2022
Statut:
ppublish
Résumé
Distinguishing vitiligo activity/stability status is pivotal in the management of patients with vitiligo. CXCL10 is a chemokine released in the tissues and sera of patients with vitiligo and an indicator of disease activity. This study aimed to assess the role of dermoscopy in detecting active and stable vitiligo by comparing the dermoscopic signs in vitiligo with Vitiligo Disease Activity Score (VIDA), clinical activity, and CXCL10 activity. Ninety-seven patients with vitiligo were enrolled in this cross-sectional study. Vitiligo activity/stability was assessed using VIDA scores, clinical examination, dermoscopy, and serum CXCL10 levels measured by enzyme-linked immunosorbent assay technique. Dermoscopic scores were calculated using BPLeFoSK score. The dermoscopic score was concordant with the VIDA score in 83.5% of patients (n = 81), clinical assessment in 97.9% (n = 95), and serum CXCL10 level in 70.1% (n = 68). Dermoscopic signs of ill-defined border, satellite lesions, and micro-Koebner and starburst appearance were more common in active vitiligo, while a well-defined border was more common in stable lesions. Dermoscopic examination is a practical, reliable, noninvasive, semi-objective tool in the assessment of vitiligo activity/stability that helps reach an informed decision on the disease status to choose the appropriate therapeutic modality.
Sections du résumé
BACKGROUND
BACKGROUND
Distinguishing vitiligo activity/stability status is pivotal in the management of patients with vitiligo. CXCL10 is a chemokine released in the tissues and sera of patients with vitiligo and an indicator of disease activity.
AIM
OBJECTIVE
This study aimed to assess the role of dermoscopy in detecting active and stable vitiligo by comparing the dermoscopic signs in vitiligo with Vitiligo Disease Activity Score (VIDA), clinical activity, and CXCL10 activity.
METHODS
METHODS
Ninety-seven patients with vitiligo were enrolled in this cross-sectional study. Vitiligo activity/stability was assessed using VIDA scores, clinical examination, dermoscopy, and serum CXCL10 levels measured by enzyme-linked immunosorbent assay technique. Dermoscopic scores were calculated using BPLeFoSK score.
RESULTS
RESULTS
The dermoscopic score was concordant with the VIDA score in 83.5% of patients (n = 81), clinical assessment in 97.9% (n = 95), and serum CXCL10 level in 70.1% (n = 68). Dermoscopic signs of ill-defined border, satellite lesions, and micro-Koebner and starburst appearance were more common in active vitiligo, while a well-defined border was more common in stable lesions.
CONCLUSION
CONCLUSIONS
Dermoscopic examination is a practical, reliable, noninvasive, semi-objective tool in the assessment of vitiligo activity/stability that helps reach an informed decision on the disease status to choose the appropriate therapeutic modality.
Substances chimiques
CXCL10 protein, human
0
Chemokine CXCL10
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4651-4658Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
Harris JE, Ezzedine K, Bibeau K, Jones K, Na L, Pandya A. 17755 Global survey investigating the prevalence of vitiligo and vitiligo signs among adults in Europe, Japan, and the United States. JAAD. 2020;83(6):AB198. doi:10.1016/j.jaad.2020.06.881
Parsad D, Sahni K. Stability in vitiligo: is there a perfect way to predict it. J Cutan Aesthet Surgery. 2013;6(2):75-82. doi:10.4103/0974-2077.112667
Njoo MD, Das PK, Bos JD, Westerhof W. Association of the Kobner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris. Arch Dermatol. 1991;135:407-413. doi:10.1001/archderm.135.4.407
Purnima G, Tejaswitha Gudivada NA, Narasimharao TV. Dermoscopy - A Tool to Assess Stability in Vitiligo. International journal of contemporary medical Research; 2017:2066.
Benzekri L, Gauthier Y, Hamada S, Hassam B. Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. Br J Dermatol. 2013;168:265-271.
Menchini G, Comacchi C, Cappugi P, Torchia D. Depigmentation patterns of nonsegmental vitiligo: a prospective study of macromorphologic changes in lesions. Am J Clin Dermatol. 2013;14:55-59. doi:10.1111/bjd.12034
Sosa JJ, Currimbhoy SD, Ukoha U, et al. Confetti-like depigmentation: a potential sign of rapidly progressing vitiligo. J Am Acad Dermatol. 2015;73(2):272-275. doi:10.1016/j.jaad.2015.05.014
Aboul-Fettouh N, Hinojosa J, Tovar-Garza A, Pandya AG. The majority of patients presenting with vitiligo have a clinical sign of activity. J Am Acad Dermatol. 2017;77:774-775. doi:10.1016/j.jaad.2017.05.027
Rao A, Gupta S, Dinda AK, et al. Study of clinical, biochemical and immunological factors determining stability of disease with generalized vitiligo undergoing melanocyte transplantation. Br J Dermatol. 2012;166:1230-1236. doi:10.1111/j.1365-2133.2012.10886.x
van Geel N, Grine L, De Wispelaere P, Mertens D, Prinsen CAC, Speeckaert R. Clinical visible signs of disease activity in vitiligo: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2012;33(9):1667-1675. doi:10.1111/jdv.15604
Abdallah M, El-Mofty M, Anbar T, et al. Egyptian vitiligo group. CXCL-10 and interleukin-6 are reliable serum markers for vitiligo activity: a multicentre cross-sectional study. Pigment Cell Melanoma Res. 2018;31(2):330-336. doi:10.1111/pcmr.12667
Lin F, Hu W, Xu W, Zhou M, Xu A. CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation. Sci Rep. 2021;11(1):18298. doi:10.1038/s41598-021-97296-2
Harris JE, Harris TH, Weninger W, Wherry EJ, Hunter CA, Turka LA. A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8+ T-cell accumulation in the skin. J Invest Dermatol. 2012;132:1869-1876. doi:10.1038/jid.2011.463
Wang XX, Wang QQ, Wu JQ, et al. Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo. Br J Dermatol. 2016;174(6):1318-1326. doi:10.1111/bjd.14416
Rashighi M, Agarwal P, Richmond JM, et al. CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med. 2014;6(223):223ra23. doi: 10.1126/scitranslmed.3007811
Nirmal B, Antonisamy B, Peter CVD, George L, George AA, Dinesh GM. Cross-sectional study of dermatoscopic findings in relation to activity in vitiligo: BPLeFoSK criteria for stability. J Cutan Aesthet Surg. 2019;12(1):36-41. doi:10.4103/JCAS.JCAS_75_18
Chan YH. Biostatistics 103: qualitative data -Tests of independence. Singapore Med J. 2003;44(10):498-503.
Spearman Rank Correlation Coefficient. The Concise Encyclopedia of Statistics. Springer; 2008. doi:10.1007/978-0-387-32833-1_379
Antonelli A, Ferrari SM, Giuggioli D, Ferrannini E, Ferri C, Fallahi P. Chemokine (C-X-C motif) ligand (CXCL10) in autoimmune diseases. Autoimmun Rev. 2014;13:272-280. doi:10.1016/j.autrev.2013.10.010
Chuh AA, Zawar V. Demonstration of residual perifollicular pigmentation in localized vitiligo-a reverse and novel application of digital epiluminescence dermoscopy. Comput Med Imaging Graph. 2004;28:213-217. doi:10.1016/j.compmedimag.2004.03.001
Bambroo M, Pande S, Khopkar US. Dermoscopy in the differentiation of Idiopathic Guttate Hypomelanosis (IGH). In: Khopkar U, ed. Dermoscopy and Trichoscopy in Diseases of the Brown Skin: Atlas and Short Text. Jaypee Brothers Medical Publishers; 2012:97-103. doi:10.4103/2229-5178.156383
Lee DY, Kim CR, Park JH, Lee JH. The incidence of leukotrichia in segmental vitiligo: implication of poor response to medical treatment. Int J Dermatol. 2011;50:925-927. doi:10.1111/j.1365-4632.2011.04914.x
Jha AK, Sonthalia S, Lallas A. Dermoscopy as an evolving tool to assess vitiligo activity. J Am Acad Dermatol. 2018;78(5):1017-1019. doi:10.1016/j.jaad.2017.12.009
Jha AK, Sonthalia S, Lallas A, Chaudhary RKP. Dermoscopy in vitiligo: diagnosis and beyond. Int J Dermatol. 2018;57(1):50-54. doi:10.1111/ijd.13795