Hydroxylated benzo[c]phenanthrene metabolites cause osteoblast apoptosis and skeletal abnormalities in fish.

Apoptosis Fish scales Monohydroxylated polycyclic aromatic hydrocarbons Osteoblasts Osteoclasts Skeletal abnormalities

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
01 Apr 2022
Historique:
received: 16 12 2021
revised: 19 02 2022
accepted: 06 03 2022
pubmed: 18 3 2022
medline: 18 3 2022
entrez: 17 3 2022
Statut: ppublish

Résumé

To study the toxicity of 3-hydroxybenzo[c]phenanthrene (3-OHBcP), a metabolite of benzo[c]phenanthrene (BcP), first we compared it with its parent compound, BcP, using an in ovo-nanoinjection method in Japanese medaka. Second, we examined the influence of 3-OHBcP on bone metabolism using goldfish. Third, the detailed mechanism of 3-OHBcP on bone metabolism was investigated using zebrafish and goldfish. The LC

Identifiants

DOI: 10.1016/j.ecoenv.2022.113401 PMID: 35298967
pubmed: 35298967
pii: S0147-6513(22)00241-X
doi: 10.1016/j.ecoenv.2022.113401
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113401

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Nobuo Suzuki (N)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan. Electronic address: nobuos@staff.kanazawa-u.ac.jp.

Masato Honda (M)

Botanical Garden, Institute of Nature and Environmental Technology, Kanazawa University, Kakuma-machi, Ishikawa 920-1192, Japan.

Masayuki Sato (M)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan.

Shuhei Yoshitake (S)

Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

Kimi Kawabe (K)

Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma, Ishikawa 920-1192, Japan.

Yoshiaki Tabuchi (Y)

Life Science Research Center, University of Toyama, Sugitani, Toyama 930-0194, Japan.

Toshiki Omote (T)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan.

Toshio Sekiguchi (T)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan.

Yukihiro Furusawa (Y)

Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Toyama 939-0398, Japan.

Akira Toriba (A)

Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi, Nagasaki 852-8521, Japan.

Ning Tang (N)

Institute of Nature and Environmental Technology, Kanazawa University, Kakuma-machi, Ishikawa 920-1192, Japan.

Yohei Shimasaki (Y)

Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

Edward G Nagato (EG)

Graduate School of Faculty of Life and Environmental Sciences, Shimane University, Matsue, Shimane 690-8504, Japan.

Lulu Zhang (L)

Institute of Nature and Environmental Technology, Kanazawa University, Kakuma-machi, Ishikawa 920-1192, Japan.

Ajai K Srivastav (AK)

Department of Zoology, D.D.U. Gorakhpur University, Gorakhpur 273-009, India.

Thumronk Amornsakun (T)

Fisheries Technology Program, Faculty of Science and Technology, Prince of Songkla University, Pattani 94000, Thailand.

Yoichiro Kitani (Y)

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan.

Hajime Matsubara (H)

Noto Center for Fisheries Science and Technology, Kanazawa University, Osaka, Noto-cho, Ishikawa 927-0552, Japan.

Takashi Yazawa (T)

Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.

Jun Hirayama (J)

Department of Clinical Engineering, Faculty of Health Sciences, Komatsu University, Komatsu, Ishikawa 923-0961, Japan.

Atsuhiko Hattori (A)

Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba 272-0827, Japan.

Yuji Oshima (Y)

Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.

Kazuichi Hayakawa (K)

Low Level Radioactivity Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Nomi city, Ishikawa 923-1224, Japan.

Classifications MeSH