Assessment of parathyroid gland cellularity by digital slide analysis.
Computer-assisted image analysis
Hyperparathyroidism
Light Microscopy
Parathyroid Adenoma
Parathyroidectomy
Surgical Pathology
Journal
Annals of diagnostic pathology
ISSN: 1532-8198
Titre abrégé: Ann Diagn Pathol
Pays: United States
ID NLM: 9800503
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
24
05
2021
revised:
01
01
2022
accepted:
25
01
2022
pubmed:
18
3
2022
medline:
24
5
2022
entrez:
17
3
2022
Statut:
ppublish
Résumé
Computer-aided examination of digital tissue images has attracted attention in recent years. Application in the field of parathyroid pathology has not been studied previously. It holds a potential to assist in the examination of parathyroid gland adenoma or hyperplasia. To explore parathyroid cell detection of slide images by digital tissue analysis and compare the results to standard human processing. 47 incisional biopsies of healthy appearing parathyroid glands were evaluated for their cellularity level. First, by the standard examination using microscopy by three independent pathologists. We compared the mean cellularity grading of the pathologists to the output of a computerized cell detection software. A disagreement was found between the standard human cellularity grading and the digital analysis output. However, the digital analysis reaches a 94% specificity and 48% sensitivity to predict high cellularity (>60% parenchymal cells). Digital analysis of parathyroid tissue can be used as a tool for hypercellularity elimination, therefore assisting in the diagnosis of parathyroid cell hyperplasia. Additional studies using more advanced algorithms are necessary for further precision enhancement.
Sections du résumé
BACKGROUND
BACKGROUND
Computer-aided examination of digital tissue images has attracted attention in recent years. Application in the field of parathyroid pathology has not been studied previously. It holds a potential to assist in the examination of parathyroid gland adenoma or hyperplasia.
OBJECTIVES
OBJECTIVE
To explore parathyroid cell detection of slide images by digital tissue analysis and compare the results to standard human processing.
METHODS
METHODS
47 incisional biopsies of healthy appearing parathyroid glands were evaluated for their cellularity level. First, by the standard examination using microscopy by three independent pathologists. We compared the mean cellularity grading of the pathologists to the output of a computerized cell detection software.
RESULTS
RESULTS
A disagreement was found between the standard human cellularity grading and the digital analysis output. However, the digital analysis reaches a 94% specificity and 48% sensitivity to predict high cellularity (>60% parenchymal cells).
CONCLUSIONS
CONCLUSIONS
Digital analysis of parathyroid tissue can be used as a tool for hypercellularity elimination, therefore assisting in the diagnosis of parathyroid cell hyperplasia. Additional studies using more advanced algorithms are necessary for further precision enhancement.
Identifiants
pubmed: 35299079
pii: S1092-9134(22)00009-0
doi: 10.1016/j.anndiagpath.2022.151907
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151907Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.