Exploring the Mechanism of Yiqi Qingre Ziyin Method in Regulating Neuropeptide Expression for the Treatment of Atrophic Rhinitis.
Computer Simulation
Databases, Genetic
Dipeptidyl Peptidase 4
Drugs, Chinese Herbal
/ pharmacology
Epithelial Cells
/ pathology
Gene Ontology
Humans
Medicine, Chinese Traditional
Metaplasia
/ pathology
Molecular Docking Simulation
Nasal Mucosa
/ immunology
Neuropeptides
/ metabolism
Rhinitis, Atrophic
/ drug therapy
Journal
Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
11
2021
revised:
29
01
2022
accepted:
09
02
2022
entrez:
18
3
2022
pubmed:
19
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Atrophic rhinitis (AR) is a chronic disease that causes severe structural changes to the nasal mucosa leading to squamous epithelial metaplasia. However, treatment regarding AR remains a major challenge. We used network pharmacology and molecular docking methods to explore the potential mechanisms of the Yiqi Qingre Ziyin method to modulate neuropeptides in the treatment of AR. The active ingredients of the Yiqi Qingre Ziyin method and their targets of action were obtained from the Traditional Chinese Medicine Systematic Pharmacology Database Analysis Platform (TCMSP). Disease targets for AR were obtained from four databases: GeneCards, PharmGKB, DrugBank, and Online Mendelian Inheritance in Man (OMIM). A total of 59 active ingredients, 39 potential targets, and 76 relevant neuropeptides were obtained after deduplication. We constructed target interaction networks with the STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed on the 14 potential target proteins. We used Cytoscape software to construct the "drug-active ingredient-potential target" and "ingredient-target-pathway" networks of the Yiqi Qingre Ziyin method for treating AR. Molecular docking results suggest that dipeptidyl peptidase 4 (
Identifiants
pubmed: 35299869
doi: 10.1155/2022/4416637
pmc: PMC8923799
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Neuropeptides
0
DPP4 protein, human
EC 3.4.14.5
Dipeptidyl Peptidase 4
EC 3.4.14.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4416637Informations de copyright
Copyright © 2022 Lixing Lu et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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