Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation.
endoplasmic reticular stress
monogenic diabetes
oxidative folding intermediate
peptide chemistry
protein folding
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
11
2021
accepted:
17
01
2022
entrez:
18
3
2022
pubmed:
19
3
2022
medline:
26
4
2022
Statut:
epublish
Résumé
The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin's biosynthetic precursor. Also designated
Identifiants
pubmed: 35299972
doi: 10.3389/fendo.2022.821069
pmc: PMC8922534
doi:
Substances chimiques
Disulfides
0
Insulin
0
Peptides
0
Proinsulin
9035-68-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
821069Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK040949
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK104618
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007250
Pays : United States
Informations de copyright
Copyright © 2022 Dhayalan, Glidden, Zaykov, Chen, Yang, Phillips, Ismail-Beigi, Jarosinski, DiMarchi and Weiss.
Déclaration de conflit d'intérêts
This study received partial funding from Calibrium, LLC. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. All authors declare no other competing interests.
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