Paternal grandmother's smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren.
ALSPAC
PROP
bitter taste
grandmother smoking in pregnancy
paternal grandmother
supertasters
transgenerational
Journal
Environmental epigenetics
ISSN: 2058-5888
Titre abrégé: Environ Epigenet
Pays: England
ID NLM: 101675941
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
10
2021
revised:
30
11
2021
accepted:
23
12
2021
entrez:
18
3
2022
pubmed:
19
3
2022
medline:
19
3
2022
Statut:
epublish
Résumé
Although there are many examples in the experimental literature of an environmental exposure in one generation impacting the phenotypes of subsequent generations, there are few studies that can assess whether such associations occur in humans. The Avon Longitudinal Study of Parents and Children (ALSPAC) has, however, been able to determine whether there are associations between grandparental exposures and their grandchildren's development. Several of our studies, including sensitivity to loud noise, have shown associations between a grandmother smoking in pregnancy and the phenotype of the grandchild. These results were mostly specific to the sex of the grandchild and to whether the prenatal (i.e. during pregnancy) smoking occurred in the maternal or paternal grandmother. Here, we have used ancestral data on prenatal smoking among the grandmothers of the ALSPAC index children to examine possible effects on the grandchild's ability to detect the bitter taste of PROP (6
Identifiants
pubmed: 35299985
doi: 10.1093/eep/dvac003
pii: dvac003
pmc: PMC8923060
doi:
Types de publication
Journal Article
Langues
eng
Pagination
dvac003Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
Références
Chem Senses. 2000 Aug;25(4):447-60
pubmed: 10944509
Chem Senses. 2016 Nov 1;41(9):737-744
pubmed: 27506221
Front Genet. 2019 Apr 05;10:314
pubmed: 31024624
Mutat Res Rev Mutat Res. 2017 Jul;773:26-50
pubmed: 28927533
Cancer Epidemiol Biomarkers Prev. 2021 Aug;30(8):1480-1488
pubmed: 33853850
J Clin Med. 2020 Jun 23;9(6):
pubmed: 32585828
Chest. 2014 Jun;145(6):1213-1218
pubmed: 24158349
Am J Hum Biol. 2014 Nov-Dec;26(6):731-9
pubmed: 25130101
Pediatr Res. 2007 May;61(5 Pt 2):30R-37R
pubmed: 17413847
PLoS One. 2014 Feb 04;9(2):e86781
pubmed: 24504157
Paediatr Perinat Epidemiol. 2001 Jan;15(1):74-87
pubmed: 11237119
BMC Genet. 2007 Jul 28;8:51
pubmed: 17662150
Sci Rep. 2017 Apr 27;7:46179
pubmed: 28448061
Ann N Y Acad Sci. 2009 Jul;1170:553-7
pubmed: 19686192
Sci Rep. 2019 Oct 28;9(1):15413
pubmed: 31659193
Front Genet. 2018 Mar 20;9:95
pubmed: 29616083
Eur J Hum Genet. 2022 Mar 28;:
pubmed: 35347270
Physiol Behav. 2003 Apr;78(4-5):625-33
pubmed: 12782217
PLoS One. 2020 Feb 24;15(2):e0229323
pubmed: 32092095
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Nature. 1964 Jun 27;202:1366
pubmed: 14210998
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Chem Senses. 2012 Nov;37(9):869-81
pubmed: 22977065
Physiol Behav. 1994 Dec;56(6):1165-71
pubmed: 7878086
Appetite. 2018 Jan 1;120:230-239
pubmed: 28888730
BMJ Open. 2014 Jul 11;4(7):e005030
pubmed: 25015471