Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
10 Mar 2022
10 Mar 2022
Historique:
received:
09
12
2021
accepted:
08
02
2022
entrez:
18
3
2022
pubmed:
19
3
2022
medline:
19
3
2022
Statut:
epublish
Résumé
Mitochondria are key regulators of energy supply and cell death. Generation of ATP within mitochondria occurs through oxidative phosphorylation (OXPHOS), a process which utilizes the four complexes (complex I-IV) of the electron transport chain and ATP synthase. Certain oncogenic mutations (
Identifiants
pubmed: 35300083
doi: 10.1021/acsmedchemlett.1c00666
pmc: PMC8919281
doi:
Types de publication
Journal Article
Langues
eng
Pagination
348-357Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
J Neurochem. 2017 Jan;140(1):170-182
pubmed: 27787897
Chem Soc Rev. 2009 Feb;38(2):606-31
pubmed: 19169468
J Org Chem. 2014 Feb 7;79(3):852-66
pubmed: 24422528
J Med Chem. 2018 Mar 22;61(6):2533-2551
pubmed: 29485874
J Med Chem. 2016 May 26;59(10):4578-600
pubmed: 27075367
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9167-71
pubmed: 9689052
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560
pubmed: 30683722
J Agric Food Chem. 1999 Aug;47(8):3381-8
pubmed: 10552661
Int J Mol Sci. 2019 Jul 05;20(13):
pubmed: 31284513
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18226-31
pubmed: 24145418
J Med Chem. 2017 May 11;60(9):4002-4022
pubmed: 28402630
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Drug Discov Today. 2005 Jan 15;10(2):149-55
pubmed: 15718164
J Med Chem. 2019 Jan 24;62(2):928-940
pubmed: 30563338
ChemMedChem. 2016 Jan 19;11(2):199-206
pubmed: 26333652
Radiat Oncol. 2014 Sep 19;9:207
pubmed: 25234922
Cancer Cell. 2013 Feb 11;23(2):143-58
pubmed: 23352126
Nature. 2013 Feb 28;494(7438):443-8
pubmed: 23417064
J Org Chem. 2010 May 21;75(10):3311-6
pubmed: 20359203
Cancer Med. 2013 Oct;2(5):611-24
pubmed: 24403227
ACS Chem Biol. 2017 Nov 17;12(11):2730-2736
pubmed: 29043777
Cancer Discov. 2012 Sep;2(9):778-90
pubmed: 22926251
Sci Rep. 2017 Apr 04;7:45465
pubmed: 28374803
J Med Chem. 2020 Jan 23;63(2):601-612
pubmed: 31859507
J Biol Chem. 2003 Mar 7;278(10):8516-25
pubmed: 12496265
Cancer Metab. 2015 Oct 20;3:11
pubmed: 26500770
ChemMedChem. 2016 Oct 19;11(20):2261-2271
pubmed: 27552707
J Biol Chem. 2020 May 22;295(21):7481-7491
pubmed: 32295842
Lancet Oncol. 2015 Jul;16(7):839-47
pubmed: 26067687