Prevalence of parkinsonism and Parkinson disease in urban and rural populations from Latin America: A community based study.

Latin America Parkinson's disease Parkinsonism Prevalence Risk factors

Journal

Lancet regional health. Americas
ISSN: 2667-193X
Titre abrégé: Lancet Reg Health Am
Pays: England
ID NLM: 9918232503006676

Informations de publication

Date de publication:
Mar 2022
Historique:
entrez: 18 3 2022
pubmed: 19 3 2022
medline: 19 3 2022
Statut: ppublish

Résumé

Age and gender specific prevalence rates for parkinsonism and Parkinson's disease (PD) are important to guide research, clinical practice, and public health planning; however, prevalence estimates in Latin America (LatAm) are limited. We aimed to estimate the prevalence of parkinsonism and PD and examine related risk factors in a cohort of elderly individuals from Latin America (LatAm). Data from 11,613 adults (65+ years) who participated in a baseline assessment of the 10/66 study and lived in six LatAm countries were analyzed to estimate parkinsonism and PD prevalence. Crude and age-adjusted prevalence were determined by sex and country. Diagnosis of PD was established using the UK Parkinson's Disease Society Brain Bank's clinical criteria. In this cohort, the prevalence of parkinsonism was 8.0% (95% CI 7.6%-8.5%), and the prevalence of PD was 2.0% (95% CI 1.7%-2.3%). PD prevalence increased with age from 1.0 to 3.5 (65-69vs. 80 years or older, The reported prevalence of PD in LatAm is similar to reports from high-income countries (HIC). A significant proportion of cases with PD did not have a previous diagnosis, nor did they seek any medical or neurological attention. These findings underscore the need to improve public health programs for populations currently undergoing rapid demographic aging and epidemiological transition. The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Sections du résumé

Background UNASSIGNED
Age and gender specific prevalence rates for parkinsonism and Parkinson's disease (PD) are important to guide research, clinical practice, and public health planning; however, prevalence estimates in Latin America (LatAm) are limited. We aimed to estimate the prevalence of parkinsonism and PD and examine related risk factors in a cohort of elderly individuals from Latin America (LatAm).
Methods UNASSIGNED
Data from 11,613 adults (65+ years) who participated in a baseline assessment of the 10/66 study and lived in six LatAm countries were analyzed to estimate parkinsonism and PD prevalence. Crude and age-adjusted prevalence were determined by sex and country. Diagnosis of PD was established using the UK Parkinson's Disease Society Brain Bank's clinical criteria.
Findings UNASSIGNED
In this cohort, the prevalence of parkinsonism was 8.0% (95% CI 7.6%-8.5%), and the prevalence of PD was 2.0% (95% CI 1.7%-2.3%). PD prevalence increased with age from 1.0 to 3.5 (65-69vs. 80 years or older,
Interpretation UNASSIGNED
The reported prevalence of PD in LatAm is similar to reports from high-income countries (HIC). A significant proportion of cases with PD did not have a previous diagnosis, nor did they seek any medical or neurological attention. These findings underscore the need to improve public health programs for populations currently undergoing rapid demographic aging and epidemiological transition.
Funding UNASSIGNED
The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Identifiants

DOI: 10.1016/j.lana.2021.100136 PMID: 35300390 PMC: PMC8920908
pubmed: 35300390
doi: 10.1016/j.lana.2021.100136
pii: S2667-193X(21)00132-0
pmc: PMC8920908
doi:

Types de publication

Journal Article

Langues

eng

Pagination

None

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

Llibre-Guerra JJ, Prina M, Sosa AL, Acosta D, Guerra M, Jiménez-Velázquez I, Salas A, Llibre-Guerra JC, Valvuerdi A, Acosta I, Peeters G, Ziegemeier E, Tanner C, Juncos J and Llibre-Rodríguez J report no conflict of interest relevant to this manuscript.

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Auteurs

Jorge J Llibre-Guerra (JJ)

Department of Neurology, Washington University School of Medicine in St. Louis, USA.
Department of Neurology, National Institute of Neurology and Neurosurgery, La Habana, Cuba.

Matthew Prina (M)

Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.

Ana Luisa Sosa (AL)

Laboratory of the Dementias, National Institute of Neurology and Neurosurgery of Mexico, National Autonomous University of Mexico, Mexico City, Mexico.

Daisy Acosta (D)

Universidad Nacional Pedro Henriquez Ureña (UNPHU), Internal Medicine Department, Geriatric Section, Santo Domingo, Dominican Republic.

Ivonne Z Jimenez-Velazquez (IZ)

Internal Medicine Department, Geriatrics Program, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.

Mariella Guerra (M)

Instituto de la Memoria Depresion y Enfermedades de Riesgo IMEDER, Lima, Perú.

Aquiles Salas (A)

Medicine Department, Caracas University Hospital, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela.

Juan C Llibre-Guerra (JC)

Department of Neurology, Hospital del Mar, Barcelona, Spain.

Adolfo Valvuerdi (A)

Medical University of Matanzas, Matanzas, Cuba.

Geeske Peeters (G)

Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

Ellen Ziegemeier (E)

Department of Neurology, Washington University School of Medicine in St. Louis, USA.

Isaac Acosta (I)

Laboratory of the Dementias, National Institute of Neurology and Neurosurgery of Mexico, National Autonomous University of Mexico, Mexico City, Mexico.

Caroline Tanner (C)

Department of Neurology, Weill Institute for Neurosciences, University of San Francisco, California, USA.

Jorge Juncos (J)

Department of Neurology, Emory University School of Medicine.

Juan J Llibre Rodriguez (JJ)

Facultad de Medicina Finlay-Albarran, Medical University of Havana, Havana, Cuba.

Classifications MeSH