The Centriole's Role in Miscarriages.
centriole
centrosome
fertility
miscarriage
sperm
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
01
2022
accepted:
14
02
2022
entrez:
18
3
2022
pubmed:
19
3
2022
medline:
19
3
2022
Statut:
epublish
Résumé
Centrioles are subcellular organelles essential for normal cell function and development; they form the cell's centrosome (a major cytoplasmic microtubule organization center) and cilium (a sensory and motile hair-like cellular extension). Centrioles with evolutionarily conserved characteristics are found in most animal cell types but are absent in egg cells and exhibit unexpectedly high structural, compositional, and functional diversity in sperm cells. As a result, the centriole's precise role in fertility and early embryo development is unclear. The centrioles are found in the spermatozoan neck, a strategic location connecting two central functional units: the tail, which propels the sperm to the egg and the head, which holds the paternal genetic material. The spermatozoan neck is an ideal site for evolutionary innovation as it can control tail movement pre-fertilization and the male pronucleus' behavior post-fertilization. We propose that human, bovine, and most other mammals-which exhibit ancestral centriole-dependent reproduction and two spermatozoan centrioles, where one canonical centriole is maintained, and one atypical centriole is formed-adapted extensive species-specific centriolar features. As a result, these centrioles have a high post-fertilization malfunction rate, resulting in aneuploidy, and miscarriages. In contrast, house mice evolved centriole-independent reproduction, losing the spermatozoan centrioles and overcoming a mechanism that causes miscarriages.
Identifiants
pubmed: 35300410
doi: 10.3389/fcell.2022.864692
pii: 864692
pmc: PMC8922021
doi:
Types de publication
Journal Article
Langues
eng
Pagination
864692Subventions
Organisme : NICHD NIH HHS
ID : R03 HD098314
Pays : United States
Informations de copyright
Copyright © 2022 Avidor-Reiss, Achinger and Uzbekov.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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