Sesquiterpene lactones from Artemisia mongolica.

Artemisia / chemistry Asteraceae / chemistry Lactones / chemistry Molecular Structure Phytochemicals Sesquiterpenes / chemistry
Anti-inflammatory Antitumor Artemisia mongolica Asteraceae Sesquiterpene lactones Single-crystal X-ray analysis

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jul 2022
Historique:
received: 16 11 2021
revised: 02 03 2022
accepted: 03 03 2022
pubmed: 19 3 2022
medline: 19 5 2022
entrez: 18 3 2022
Statut: ppublish

Résumé

Twelve undescribed sesquiterpene lactones and seven known sesquiterpene lactones were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data. The absolute configurations of mongolicolide A (1), mongolicolide C (3), 1R, 3S-Dihydroxy-7S, 11R-germacra-4Z.9Z-dien-12, 6S-olide (5), indicumolide E (9), indicumolide F (10), and indicumolide G (11) were determined by single-crystal X-ray crystallography. The X-ray crystal structure of artabsinolide E (15) was reported for the first time. In addition, beibersteneolide-B (13) showed moderate anti-inflammatory activity and marked antitumor activity, artemyriantholide E (18) show moderate antitumor activity.

Identifiants

DOI: 10.1016/j.phytochem.2022.113158 PMID: 35301035
pubmed: 35301035
pii: S0031-9422(22)00074-7
doi: 10.1016/j.phytochem.2022.113158
pii:
doi:

Substances chimiques

Lactones 0
Phytochemicals 0
Sesquiterpenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113158

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Ziwei Zhu (Z)

The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of the Chinese Academy of Sciences, Beijing, 100039, China.

Ablajan Turak (A)

The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.

Haji Akber Aisa (HA)

The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. Electronic address: haji@ms.xjb.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Artemisia › Sesquiterpene lactones from Artemisia mongolica.
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Sesquiterpene lactones from Artemisia mongolica.
questionsmedicales.fr › Composés chimiques organiques › Lactones › Sesquiterpene lactones from Artemisia mongolica.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Sesquiterpene lactones from Artemisia mongolica.
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Sesquiterpene lactones from Artemisia mongolica.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Sesquiterpene lactones from Artemisia mongolica.