Trichloroethylene modifies energy metabolites in the amniotic fluid of Wistar rats.
Amnio acids
Amniotic fluid
Metabolism
Metabolomics
Pregnancy
Rat
Short chain fatty acid
Trichloroethylene
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
03
10
2021
revised:
05
03
2022
accepted:
11
03
2022
pubmed:
19
3
2022
medline:
6
4
2022
entrez:
18
3
2022
Statut:
ppublish
Résumé
Exposure to trichloroethylene (TCE), an industrial solvent, is associated with several adverse pregnancy outcomes in humans and decreased fetal weight in rats. However, effects of TCE on energy metabolites in amniotic fluid, which have associations with pregnancy outcomes, has not been published previously. In the current exploratory study, timed-pregnant Wistar rats were exposed to 480 mg TCE/kg/day via vanilla wafer or to vehicle (wafer) alone from gestational day (GD) 6-16. Amniotic fluid collected on GD 16 was analyzed for metabolites important in energy metabolism using short chain fatty acid and tricarboxylic acid plus platforms (N = 4 samples/sex/treatment). TCE decreased concentrations of the following metabolites in amniotic fluid for both fetal sexes: 6-phosphogluconate, guanosine diphosphate, adenosine diphosphate, adenosine triphosphate, and flavin adenine dinucleotide. TCE decreased fructose 1,6-bisphosphate and guanosine triphosphate concentrations in amniotic fluid of male but not female fetuses. Moreover, TCE decreased uridine diphosphate-D-glucuronate concentrations, and increased arginine and phosphocreatine concentrations, in amniotic fluid of female fetuses only. No metabolites were increased in amniotic fluid of male fetuses. Pathway analysis suggested that TCE altered folate biosynthesis and pentose phosphate pathway in both sexes. Using metabolite ratios to investigate changes within specific pathways, some ratio alterations, including those in arginine metabolism and phenylalanine metabolism, were detected in females only. Ratio analysis also suggested enzymes, including gluconokinase, as potential TCE targets. Together, results from this exploratory study suggest that TCE differentially modified energy metabolites in amniotic fluid based on sex. These findings may inform future studies of TCE reproductive toxicity.
Identifiants
pubmed: 35301063
pii: S0890-6238(22)00030-2
doi: 10.1016/j.reprotox.2022.03.004
pmc: PMC9000924
mid: NIHMS1790126
pii:
doi:
Substances chimiques
Solvents
0
Trichloroethylene
290YE8AR51
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-92Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES017198
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK097153
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007062
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD079342
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES028802
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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