Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms.

Animals Autism Spectrum Disorder / genetics Autistic Disorder Circadian Rhythm Mice NAV1.2 Voltage-Gated Sodium Channel / genetics Quality of Life Sleep
Autism spectrum disorder Channelopathy Circadian clock Nav1.2 Neurodevelopmental disorder Sleep disorder Voltage-gated sodium channel

Journal

Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169

Informations de publication

Date de publication:
15 06 2022
Historique:
received: 14 10 2021
revised: 21 02 2022
accepted: 09 03 2022
pubmed: 19 3 2022
medline: 21 4 2022
entrez: 18 3 2022
Statut: ppublish

Résumé

Autism spectrum disorder (ASD) affects ~2% of the population in the US, and monogenic forms of ASD often result in the most severe manifestation of the disorder. Recently, SCN2A has emerged as a leading gene associated with ASD, of which abnormal sleep pattern is a common comorbidity. SCN2A encodes the voltage-gated sodium channel Na

Identifiants

DOI: 10.1016/j.nbd.2022.105690 PMID: 35301122 PMC: PMC9018617
pubmed: 35301122
pii: S0969-9961(22)00081-X
doi: 10.1016/j.nbd.2022.105690
pmc: PMC9018617
mid: NIHMS1790808
pii:
doi:

Substances chimiques

NAV1.2 Voltage-Gated Sodium Channel 0
Scn2a protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105690

Subventions

Organisme : NCI NIH HHS
ID : R01 CA212403
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117585
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS123154
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Zhixiong Ma (Z)

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Muriel Eaton (M)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Yushuang Liu (Y)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Jingliang Zhang (J)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Xiaoling Chen (X)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Xinyu Tu (X)

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.

Yiqiang Shi (Y)

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.

Zhefu Que (Z)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Kyle Wettschurack (K)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA.

Zaiyang Zhang (Z)

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.

Riyi Shi (R)

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.

Yueyi Chen (Y)

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.

Adam Kimbrough (A)

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.

Nadia A Lanman (NA)

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.

Leah Schust (L)

FamilieSCN2A Foundation, P.O. Box 82, East Longmeadow, MA 01028, USA.

Zhuo Huang (Z)

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address: huangz@hsc.pku.edu.cn.

Yang Yang (Y)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy & Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47906, USA. Electronic address: yangyang@purdue.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.2 › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Deficiency of autism-related Scn2a gene in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Deficiency of autism-related Scn2a gene in...