Comprehensive analysis of cytokine adsorption properties of polymethyl methacrylate (PMMA) membrane material.
Adsorption
Cytokine
Hemofilter
Polymethyl methacrylate
Journal
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
ISSN: 1619-0904
Titre abrégé: J Artif Organs
Pays: Japan
ID NLM: 9815648
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
17
10
2021
accepted:
25
02
2022
pubmed:
19
3
2022
medline:
11
11
2022
entrez:
18
3
2022
Statut:
ppublish
Résumé
In acute kidney injury caused by sepsis (septic AKI), excessive production of inflammatory mediators is believed to be involved in deterioration of the disease. Renal replacement therapy using a polymethyl methacrylate (PMMA) membrane hemofilter improves the pathological condition of septic AKI by adsorbing and removing inflammatory cytokines. However, the adsorption properties of the PMMA membrane are unclear. In this study, we comprehensively analyzed the adsorption of 48 different cytokines in human plasma to PMMA and polysulfone (PS) membranes. Seventy-nine percent (38/48) of the cytokines were adsorbed more efficiently to the PMMA membrane than the PS membrane, which indicates that the PMMA membrane has high cytokine adsorption ability. The adsorption rate tended to be higher for the cytokines with lower molecular weight, and there was a significant correlation between the molecular weight of the cytokines and the adsorption rates. Electron microscopy showed that the PMMA hollow fiber membrane had a uniform internal structure from the inner to the outer layers of the membrane and had nano-pores inside the membrane that may have contributed to the adsorption of proteins with a specific molecular weight range. The clinical efficacy of a PMMA membrane hemofilter with cytokine adsorption properties against septic AKI needs further investigation including the evaluation of filtration performance of the hemofilters.
Identifiants
pubmed: 35301606
doi: 10.1007/s10047-022-01323-6
pii: 10.1007/s10047-022-01323-6
pmc: PMC9643267
doi:
Substances chimiques
Polymethyl Methacrylate
9011-14-7
Cytokines
0
Membranes, Artificial
0
polysulfone P 1700
25135-51-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
343-349Informations de copyright
© 2022. The Author(s).
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