Optogenetic manipulations of CeA-CRF neurons modulate pain- and anxiety-like behaviors in neuropathic pain and control rats.

Animals Anxiety Corticotropin-Releasing Hormone Neuralgia / therapy Neurons Optogenetics Rats Rats, Transgenic
Amygdala Behavior CRF Neuropathic pain Optogenetics

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 06 2022
Historique:
received: 08 11 2021
revised: 07 03 2022
accepted: 12 03 2022
pubmed: 20 3 2022
medline: 8 4 2022
entrez: 19 3 2022
Statut: ppublish

Résumé

The amygdala plays a critical role in the emotional-affective component of pain and pain modulation. The central nucleus of amygdala (CeA) serves major output functions and has been linked to pain-related behaviors. Corticotropin releasing factor (CRF) in the CeA has emerged as an important modulator of pain and affective disorders. Here we measured the effects of optogenetic manipulation of CeA-CRF neurons on pain-related behaviors in a rat neuropathic pain model and under control conditions. Emotional-affective behaviors (vocalizations), mechanosensitivity (electronic von Frey anesthesiometer and calibrated forceps), and anxiety-like behaviors (open field test and elevated plus maze) were assessed in adult rats 1 week and 4 weeks after spinal nerve ligation (SNL model) and sham surgery (control). For optogenetic silencing or activation of CRF neurons, a Cre-inducible viral vector encoding enhanced halorhodopsin (eNpHR

Identifiants

DOI: 10.1016/j.neuropharm.2022.109031 PMID: 35304173 PMC: PMC9352141
pubmed: 35304173
pii: S0028-3908(22)00090-9
doi: 10.1016/j.neuropharm.2022.109031
pmc: PMC9352141
mid: NIHMS1827308
pii:
doi:

Substances chimiques

Corticotropin-Releasing Hormone 9015-71-8

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109031

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS038261
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106902
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Références

Pain. 2007 Jan;127(1-2):161-72
pubmed: 17055162
Eur J Neurosci. 1997 Feb;9(2):299-305
pubmed: 9058050
Neuroscience. 2002;112(3):605-17
pubmed: 12074902
Nat Neurosci. 2015 Sep;18(9):1213-25
pubmed: 26308982
Mol Pain. 2014 May 29;10:32
pubmed: 24884567
Front Neurosci. 2015 Dec 24;9:487
pubmed: 26733798
Pain. 2017 Apr;158(4):747-759
pubmed: 28225716
Pain. 2017 Dec;158(12):2376-2385
pubmed: 28832396
J Neurophysiol. 2009 Oct;102(4):2253-64
pubmed: 19625541
Mol Pain. 2015 Aug 28;11:51
pubmed: 26311432
Neuropharmacology. 2015 Aug;95:388-94
pubmed: 25912637
Pain. 1992 Sep;50(3):355-363
pubmed: 1333581
eNeuro. 2021 Jan 22;8(1):
pubmed: 33188006
Front Behav Neurosci. 2020 Aug 26;14:145
pubmed: 33005134
Mol Brain. 2020 Sep 18;13(1):128
pubmed: 32948219
Nat Commun. 2019 Mar 18;10(1):1238
pubmed: 30886240
Neuropharmacology. 2020 Jun 15;170:108052
pubmed: 32188569
J Neurosci. 2016 Jan 20;36(3):837-50
pubmed: 26791214
J Neurosci. 2020 Apr 22;40(17):3424-3442
pubmed: 32217613
J Neurosci. 2008 Apr 9;28(15):3861-76
pubmed: 18400885
Mol Pain. 2009 Apr 28;5:21
pubmed: 19400952
J Neurosci. 2005 Nov 16;25(46):10717-28
pubmed: 16291945
Int J Mol Sci. 2020 May 11;21(9):
pubmed: 32403385
Behav Brain Res. 2007 Sep 4;182(2):261-73
pubmed: 17467067
Behav Brain Res. 2002 Aug 21;134(1-2):49-57
pubmed: 12191791
Neuron. 2017 Jan 4;93(1):164-178
pubmed: 28017470
Mol Pain. 2007 Jun 05;3:13
pubmed: 17550594
Handb Behav Neurosci. 2020;26:101-113
pubmed: 33889063
Neuroimage. 2009 Sep;47(3):1007-14
pubmed: 19497372
J Neurosci. 2017 Feb 8;37(6):1378-1393
pubmed: 28011743
Brain Sci. 2021 Oct 11;11(10):
pubmed: 34679403
Neuropharmacology. 2019 Nov 1;158:107706
pubmed: 31306647
ACS Chem Neurosci. 2018 Sep 19;9(9):2252-2261
pubmed: 29630339
Pain. 2019 Jan;160(1):136-150
pubmed: 30157131
Pain. 2020 Jan;161(1):166-176
pubmed: 31479066
Neuron. 2015 Aug 5;87(3):605-20
pubmed: 26212712
Mol Pain. 2007 Mar 28;3:8
pubmed: 17391515
J Neurophysiol. 2007 Jun;97(6):3893-904
pubmed: 17392412
Neuropharmacology. 2021 Mar 1;185:108456
pubmed: 33444637
eNeuro. 2018 Feb 6;5(1):
pubmed: 29445764
Biomed Eng Online. 2021 Jun 5;20(1):55
pubmed: 34090446
Nat Neurosci. 2013 Mar;16(3):332-9
pubmed: 23354330
J Neurophysiol. 2003 Feb;89(2):716-27
pubmed: 12574449
Neurosci Lett. 2010 Feb 26;471(1):43-7
pubmed: 20067820
J Neurosci. 2003 Jan 1;23(1):52-63
pubmed: 12514201
Cell Rep. 2019 Oct 8;29(2):332-346.e5
pubmed: 31597095
Front Pharmacol. 2021 May 25;12:668337
pubmed: 34113253
Mol Pain. 2018 Jan-Dec;14:1744806918807102
pubmed: 30270724
Nature. 2010 Nov 11;468(7321):270-6
pubmed: 21068836
Mol Pain. 2018 Jan-Dec;14:1744806918804441
pubmed: 30209982
Cell Rep. 2019 Oct 1;29(1):13-21.e4
pubmed: 31577943

Auteurs

Mariacristina Mazzitelli (M)

Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Vadim Yakhnitsa (V)

Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Benjamin Neugebauer (B)

Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Volker Neugebauer (V)

Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA. Electronic address: volker.neugebauer@ttuhsc.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Corticolibérine › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › Cellules › Neurones › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Optogénétique › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Optogenetic manipulations of CeA-CRF neurons...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rats transgéniques › Optogenetic manipulations of CeA-CRF neurons...