Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
18 03 2022
18 03 2022
Historique:
received:
03
09
2020
accepted:
08
02
2022
entrez:
19
3
2022
pubmed:
20
3
2022
medline:
6
4
2022
Statut:
epublish
Résumé
Dysregulated glucagon secretion from pancreatic alpha-cells is a key feature of type-1 and type-2 diabetes (T1D and T2D), yet our mechanistic understanding of alpha-cell function is underdeveloped relative to insulin-secreting beta-cells. Here we show that the enzyme acetyl-CoA-carboxylase 1 (ACC1), which couples glucose metabolism to lipogenesis, plays a key role in the regulation of glucagon secretion. Pharmacological inhibition of ACC1 in mouse islets or αTC9 cells impaired glucagon secretion at low glucose (1 mmol/l). Likewise, deletion of ACC1 in alpha-cells in mice reduced glucagon secretion at low glucose in isolated islets, and in response to fasting or insulin-induced hypoglycaemia in vivo. Electrophysiological recordings identified impaired K
Identifiants
pubmed: 35304577
doi: 10.1038/s42003-022-03170-w
pii: 10.1038/s42003-022-03170-w
pmc: PMC8933412
doi:
Substances chimiques
Acetyl Coenzyme A
72-89-9
Glucagon
9007-92-5
ACC1 protein, mouse
EC 6.4.1.2
Acetyl-CoA Carboxylase
EC 6.4.1.2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
238Subventions
Organisme : Medical Research Council
ID : MC_UU_12012/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V011979/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T002107/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P020666/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT084210Z/07/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T00875X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT088357Z/09/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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