Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice.

Animals Cell Proliferation Embryonic Stem Cells / metabolism Hippocampus Mice Mice, Inbred C57BL Neural Stem Cells / metabolism Neurogenesis / physiology Toll-Like Receptor 5 / metabolism
adult stem cells animal models cell culture nervous system neural differentiation neural stem cells (NSCs) neuron

Journal

Stem cells (Dayton, Ohio)
ISSN: 1549-4918
Titre abrégé: Stem Cells
Pays: England
ID NLM: 9304532

Informations de publication

Date de publication:
31 03 2022
Historique:
received: 26 04 2021
accepted: 09 12 2021
pubmed: 20 3 2022
medline: 2 4 2022
entrez: 19 3 2022
Statut: ppublish

Résumé

Toll-like receptors (TLRs) make a crucial contribution to the innate immune response. TLR5 was expressed in embryoid body derived from mouse embryonic stem cells (mESCs) and βIII-tubulin-positive cells under all-trans retinoic acid-treated condition. TLR5 was upregulated during neural differentiation from mESCs and augmented the neural differentiation of mESCs via nuclear factor-κB and interleukin 6/CREB pathways. Besides, TLR5 was expressed in SOX2- or doublecortin-positive cells in the subgranular zone of the hippocampal dentate gyrus where adult neurogenesis occurs. TLR5 inhibited the proliferation of adult hippocampal neural stem cells (NSCs) by regulating the cell cycle and facilitated the neural differentiation from the adult hippocampal NSCs via JNK pathway. Also, TLR5 deficiency impaired fear memory performance in mice. Our data suggest that TLR5 is a crucial modulator of neurogenesis from mESCs and adult hippocampal NSCs in mice and represents a new therapeutic target in neurological disorders related to cognitive function.

Identifiants

DOI: 10.1093/stmcls/sxab025 PMID: 35304896
pubmed: 35304896
pii: 6532683
doi: 10.1093/stmcls/sxab025
doi:

Substances chimiques

Tlr5 protein, mouse 0
Toll-Like Receptor 5 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

303-317

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Auteurs

Kyung-Joo Seong (KJ)

Dental Science Research Institute, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Seungho Choi (S)

Dental Science Research Institute, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Hyun-Gwan Lee (HG)

Department of Oceanography, Marine Ecological Disturbing and Harmful Organisms Research Center, BK21+ Climate Change and Coastal Ecosystem Prediction Research Center, Chonnam National University, Gwangju, Republic of Korea.

Joon Haeng Rhee (JH)

National Research Laboratory of Molecular Microbial Pathogenesis, Research Institute of Vibrio Infection and Genome Research Center for Enteropathogenic Bacteria, Department of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea.

Jin Ho Lee (JH)

School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.

Jeong-Tae Koh (JT)

Dental Science Research Institute, Hard-tissue Biointerface Research Center, Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Sun-Hun Kim (SH)

Dental Science Research Institute, Hard-tissue Biointerface Research Center, Department of Oral Anatomy, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Won-Seok Choi (WS)

School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea.

Ji-Yeon Jung (JY)

Dental Science Research Institute, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Won-Jae Kim (WJ)

Dental Science Research Institute, Hard-tissue Biointerface Research Center, Department of Oral Physiology, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.
ORCID: 0000-0001-6549-744X

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Toll-Like Receptor 5 Promotes the Neurogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-5 › Toll-Like Receptor 5 Promotes the Neurogenesis...