Infection Polygenic Factors Account for a Small Proportion of the Relationship Between Infections and Mental Disorders.
Attention Deficit Disorder with Hyperactivity
/ epidemiology
Bipolar Disorder
/ epidemiology
Depressive Disorder, Major
/ epidemiology
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Mental Disorders
/ epidemiology
Multifactorial Inheritance
/ genetics
Risk Factors
Schizophrenia
/ epidemiology
Concordance index
Genetic correlation
Mediation analysis
Pleiotropy
Polygenic risk score
iPSYCH
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
14
06
2021
revised:
07
01
2022
accepted:
07
01
2022
pubmed:
21
3
2022
medline:
2
8
2022
entrez:
20
3
2022
Statut:
ppublish
Résumé
Several recent studies have suggested a role for infections in the development of mental disorders; however, the genetic contribution to this association is understudied. We use the iPSYCH case-cohort genotyped sample (n = 65,534) and Danish health care registry data to study the genetic association between infections and mental disorders. To test the hypothesis that these associations are due to genetic pleiotropy, we estimated the genetic correlation between infection and mental disorders. Polygenic risk scores (PRSs) were used to assess whether genetic pleiotropy of infections and mental disorders was mediated by actual infection diagnoses. We observed that schizophrenia, attention-deficit/hyperactivity disorder, major depressive disorder, bipolar disorder, and posttraumatic stress disorder (r Infections and mental disorders share a modest genetic architecture. Infection PRSs can predict risk of certain mental disorders; however, this effect is moderate. Finally, recorded infections partially explain the relationship between infection PRSs and mental disorders.
Sections du résumé
BACKGROUND
Several recent studies have suggested a role for infections in the development of mental disorders; however, the genetic contribution to this association is understudied.
METHODS
We use the iPSYCH case-cohort genotyped sample (n = 65,534) and Danish health care registry data to study the genetic association between infections and mental disorders. To test the hypothesis that these associations are due to genetic pleiotropy, we estimated the genetic correlation between infection and mental disorders. Polygenic risk scores (PRSs) were used to assess whether genetic pleiotropy of infections and mental disorders was mediated by actual infection diagnoses.
RESULTS
We observed that schizophrenia, attention-deficit/hyperactivity disorder, major depressive disorder, bipolar disorder, and posttraumatic stress disorder (r
CONCLUSIONS
Infections and mental disorders share a modest genetic architecture. Infection PRSs can predict risk of certain mental disorders; however, this effect is moderate. Finally, recorded infections partially explain the relationship between infection PRSs and mental disorders.
Identifiants
pubmed: 35305821
pii: S0006-3223(22)00048-8
doi: 10.1016/j.biopsych.2022.01.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-290Subventions
Organisme : NIMH NIH HHS
ID : U01 MH094432
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.