Structural characterization of a polysaccharide from Trametes sanguinea Lloyd with immune-enhancing activity via activation of TLR4.

Animals Mice Polyporaceae Polysaccharides / chemistry RAW 264.7 Cells Tandem Mass Spectrometry Toll-Like Receptor 4 Trametes
Activation of TLR4 Immune-enhancing activity Polysaccharide Structural characterization Trametes sanguinea

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 May 2022
Historique:
received: 16 09 2021
revised: 30 01 2022
accepted: 12 03 2022
pubmed: 21 3 2022
medline: 15 4 2022
entrez: 20 3 2022
Statut: ppublish

Résumé

A bioactive polysaccharide (TS2-2A) with a molecular weight of 15 kDa was isolated from Trametes sanguinea Lloyd, a medicinal food homologous fungus, by water extraction-alcohol precipitation and chromatographic separation. NMR analysis of polysaccharide and MS/MS analysis of its oligosaccharide indicated that TS2-2A featured a novel straight chain with a backbone of 1,3-α-d-glucopyranose and 1,4-β-d-glucopyranose at a molar ratio of 1:4. Moreover, TS2-2A, recognized by Toll-like receptor 4 (TLR4), stimulated RAW 264.7 macrophages to release related cytokines and contributed to immune-enhancing effects. Briefly, with remarkable immune-enhancing activity and noncytotoxicity, TS2-2A was proposed to be a potential immune enhancer for supplementing drugs or functional foods.

Identifiants

DOI: 10.1016/j.ijbiomac.2022.03.072 PMID: 35306017
pubmed: 35306017
pii: S0141-8130(22)00542-6
doi: 10.1016/j.ijbiomac.2022.03.072
pii:
doi:

Substances chimiques

Polysaccharides 0
Tlr4 protein, mouse 0
Toll-Like Receptor 4 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1026-1038

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Mengting Zhang (M)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.

Mengxia Yan (M)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.

Jiaqian Yang (J)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.

Fenfen Li (F)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.

Yiran Wang (Y)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.

Kaiyuan Feng (K)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.

Sanying Wang (S)

Zhejiang Provincial Key Lab of Geriatrics, Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310030, PR China.

Nengming Lin (N)

Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China. Electronic address: lnm1013@zju.edu.cn.

Yiqi Wang (Y)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China. Electronic address: wangyiqi2011@126.com.

Bo Yang (B)

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China. Electronic address: ybtcm@zcmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural characterization of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Structural characterization of a...
questionsmedicales.fr › Eucaryotes › Champignons › Basidiomycota › Polyporales › Polyporaceae › Structural characterization of a...
questionsmedicales.fr › Glucides › Polyosides › Structural characterization of a...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Structural characterization of a...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Structural characterization of a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › Structural characterization of a...
questionsmedicales.fr › Eucaryotes › Champignons › Basidiomycota › Polyporales › Coriolaceae › Trametes › Structural characterization of a...