Antibody responses after two doses of SARS-CoV-2 mRNA-1273 vaccine in an individual with history of COVID-19 re-infection.
COVID-19
SARS-CoV-2
antispike protein IgG antibody
neutralizing antibody
re-infection
vaccine
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
24
02
2022
revised:
10
03
2022
accepted:
12
03
2022
pubmed:
21
3
2022
medline:
18
5
2022
entrez:
20
3
2022
Statut:
ppublish
Résumé
We present a case of a 58-year-old Japanese man with a history of 2 previous COVID-19 infections, who received 2 doses of mRNA-1273 vaccine. We are not aware of any previous study regarding antibody tendency after 2 infections and 2 vaccinations. We evaluated his IgG titer of antispike protein and neutralizing activity from the first infection before and after 2 doses of vaccine. Both antispike IgG titer and neutralizing activity showed a tendency to decline almost 1 year after initial infection; they rapidly increased after the first vaccination, and they remained high after the second vaccination. Although this is a single case report, it seems to have generalizability because the findings are consistent with previous reports regarding single infections or 3 doses of vaccination. Our findings suggest that a single booster shot may provide sufficient protection and aid the understanding of immunologic responses of vaccination in patients with COVID-19 with history of re-infection.
Identifiants
pubmed: 35306204
pii: S1201-9712(22)00155-2
doi: 10.1016/j.ijid.2022.03.017
pmc: PMC8925083
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Immunoglobulin G
0
2019-nCoV Vaccine mRNA-1273
EPK39PL4R4
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-20Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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