Relevance of cortisol and copeptin blood concentration changes in an experimental pain model.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 03 2022
19 03 2022
Historique:
received:
20
08
2021
accepted:
03
03
2022
entrez:
20
3
2022
pubmed:
21
3
2022
medline:
6
5
2022
Statut:
epublish
Résumé
The effect of pain and analgesics on stress biomarkers is not well studied. We evaluated the effect of acute pain and analgesics on serum cortisol and copeptin in an experimental pain model in healthy volunteers. Healthy volunteers presented at 8 a.m. for an experimental pain stimulation. Cortisol and copeptin levels were measured before, during and after electrophysiological stimulation, first before and then during opioid delivery. Difference in biomarker levels compared to baseline levels was calculated, and potential influencing factors were evaluated by linear regression analysis. Cortisol decreased by 13% during the 10 min of rest at baseline, but copeptin did not change significantly. Cortisol had a median decrease of -24% or -83 nmol/l (-44 to -124 nmol/l, p = 0.0002) during the electrophysiological stimulation training session, while the median difference for copeptin was -22% or -1.01 pmol/l (-2.35 to 0.08 pmol/l, p = 0.0003). After administration of opioids, cortisol did not decrease but increased by 3% (p = 0.043), indicating an increasing opioids effect on cortisol. This effect was not visible for copeptin (median change -0.003 pmol/l (-0.50 to 0.24), p = 0.45). In this experimental pain model performed in the morning, moderate pain did not have a relevant effect on cortisol or copeptin levels, whereas opioids led to a discrete peak of cortisol.Clinicaltrials.gov identifier: NCT01975753 (registered on November 5, 2013, before start of recruitment).
Identifiants
pubmed: 35306524
doi: 10.1038/s41598-022-08657-4
pii: 10.1038/s41598-022-08657-4
pmc: PMC8934351
doi:
Substances chimiques
Analgesics, Opioid
0
Biomarkers
0
Glycopeptides
0
copeptins
0
Hydrocortisone
WI4X0X7BPJ
Banques de données
ClinicalTrials.gov
['NCT01975753']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4767Informations de copyright
© 2022. The Author(s).
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