Development and validation of a risk score for prediction of clinical success after duodenal stenting for malignant gastric outlet obstruction.
EUS-guided gastroenterostomy
gastric cancer
gastric outlet obstruction
pancreatic cancer
self-expandable metal stent
Journal
Expert review of gastroenterology & hepatology
ISSN: 1747-4132
Titre abrégé: Expert Rev Gastroenterol Hepatol
Pays: England
ID NLM: 101278199
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
pubmed:
22
3
2022
medline:
28
4
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
To develop and validate a risk score for predicting clinical success after duodenal stenting using self-expanding metallic stents (SEMS) for malignant gastric outlet obstruction (GOO). Consecutive patients who underwent duodenal stenting for malignant GOO were evaluated. Potential predictors of clinical success were determined by uni/multivariate logistic regression analysis.Multiplication of the regression coefficients of the logistic regression model by a factor of two and rounding to obtain easy-to-use point numbers enabling the calculation of the score. Using 10-fold cross-validation, the model was internally validated. One hundred twelve patients were included. Clinical success was achieved in 93 (83.0%) patients. On multivariate logistic regression, selected age ≤65 years (p = 0.05, 1.5 points), stenosis type I (p = 0.04, 3 points), and pancreatic cancer (p = 0.01, 3.5 points) were significant predictors of clinical success. On the Receiver Operating Characteristic (ROC) analysis, a score of 5 had higher specificity and sensitivity. Our score could be useful at identifying, among poor surgical candidates, patients more likely to benefit from SEMS.
Sections du résumé
BACKGROUND
UNASSIGNED
To develop and validate a risk score for predicting clinical success after duodenal stenting using self-expanding metallic stents (SEMS) for malignant gastric outlet obstruction (GOO).
RESEARCH DESIGN AND METHODS
UNASSIGNED
Consecutive patients who underwent duodenal stenting for malignant GOO were evaluated. Potential predictors of clinical success were determined by uni/multivariate logistic regression analysis.Multiplication of the regression coefficients of the logistic regression model by a factor of two and rounding to obtain easy-to-use point numbers enabling the calculation of the score. Using 10-fold cross-validation, the model was internally validated.
RESULTS
UNASSIGNED
One hundred twelve patients were included. Clinical success was achieved in 93 (83.0%) patients. On multivariate logistic regression, selected age ≤65 years (p = 0.05, 1.5 points), stenosis type I (p = 0.04, 3 points), and pancreatic cancer (p = 0.01, 3.5 points) were significant predictors of clinical success. On the Receiver Operating Characteristic (ROC) analysis, a score of 5 had higher specificity and sensitivity.
CONCLUSION
UNASSIGNED
Our score could be useful at identifying, among poor surgical candidates, patients more likely to benefit from SEMS.
Identifiants
pubmed: 35306934
doi: 10.1080/17474124.2022.2056445
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM