Early versus late intubation in COVID-19 patients failing helmet CPAP: A quantitative computed tomography study.
COVID-19
CPAP
Computed tomography
Intubation
Mechanical ventilation
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
24
01
2022
revised:
02
03
2022
accepted:
15
03
2022
pubmed:
22
3
2022
medline:
13
4
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
To describe the effects of timing of intubation in COVID-19 patients that fail helmet continuous positive airway pressure (h-CPAP) on progression and severity of disease. COVID-19 patients that failed h-CPAP, required intubation, and underwent chest computed tomography (CT) at two levels of positive end-expiratory pressure (PEEP, 8 and 16 cmH Fifty-two patients were included and classified in early (h-CPAP for ≤2 days, N = 26) and late groups (h-CPAP for >2 days, N = 26). Patients in the late compared to early intubation group presented: 1) lower respiratory system compliance (median difference, MD -7 mL/cmH In COVID-19 patients receiving h-CPAP, late intubation was associated with worse clinical presentation at ICU admission and more advanced disease. The possible detrimental effects of delaying intubation should be carefully considered in these patients.
Identifiants
pubmed: 35307564
pii: S1569-9048(22)00048-9
doi: 10.1016/j.resp.2022.103889
pmc: PMC8928743
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103889Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL144461
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
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