Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.
Brain network
Cortical thickness
Depression
PTSD
Structural covariance
Surface area
Journal
Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
13
09
2021
revised:
10
02
2022
accepted:
18
02
2022
pubmed:
22
3
2022
medline:
14
9
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA). Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2-148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks. Patients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks. Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD.
Sections du résumé
BACKGROUND
Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).
METHODS
Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2-148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks.
RESULTS
Patients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks.
CONCLUSIONS
Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD.
Identifiants
pubmed: 35307575
pii: S2451-9022(22)00047-7
doi: 10.1016/j.bpsc.2022.02.008
pmc: PMC9835553
mid: NIHMS1856371
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
935-948Subventions
Organisme : NIMH NIH HHS
ID : R21 MH098198
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS096116
Pays : United States
Organisme : NIMH NIH HHS
ID : L30 MH114379
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119227
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110483
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH018931
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH092526
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH118467
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059874
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD003352
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH122774
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH109274
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH131532
Pays : United States
Organisme : RRD VA
ID : IK2 RX002922
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103291
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113574
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH112956
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH118428
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105355
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111671
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106574
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH101976
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000454
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH125277
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH112873
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH043454
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH102634
Pays : United States
Informations de copyright
Copyright © 2022 Society of Biological Psychiatry. All rights reserved.
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