Efficacy of prophylactic laser retinopexy in acute retinal necrosis: A systematic review and meta-analysis.
Acute retinal necrosis
Meta-analysis
Prophylactic laser retinopexy
Rhegmatogenous retinal detachment
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
06
06
2021
accepted:
12
11
2021
pubmed:
22
3
2022
medline:
25
5
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
We performed a systematic review and meta-analysis to assess the role of prophylactic laser retinopexy in preventing rhegmatogenous retinal detachment (RRD) in acute retinal necrosis (ARN). Pubmed, Embase and Cochrane databases were searched for eligible studies from inception to July 2020. Comprehensive clinical demographics were extracted from each study by two independent investigators. A random effects model was selected to analyze the OR of RRD risk and visual outcome with 95%CI. Subsequent subgroup and sensitivity analysis were conducted to evaluate the source of heterogeneity. A total of eight studies and 247 eyes (111 prophylactic laser retinopexy eyes and 136 eyes receiving antiviral treatment) were included in this analysis. There was moderate statistical heterogeneity across all studies. When compared with routine antiviral treatment alone, RRD risk decreased in patients receiving prophylactic laser retinopexy, however, this was not statistically significant (P = 0.09, OR = 0.42, 95%CI: 0.15-1.15). There was significant improvement in BCVA during the follow-up period in the prophylactic laser retinopexy subgroup (P = 0.01, WMD = - 0.98, 95%CI: - 1.74, - 0.22). Based on current analysis, our results did not support convincing evidence of prophylactic laser in preventing RRD. Future studies featuring high-quality, multicenter trials will be required to correct baseline characteristics. This meta-analysis has been retrospectively registered in Prospero (registration number: CRD42020201008).
Identifiants
pubmed: 35307785
doi: 10.1007/s10792-021-02131-2
pii: 10.1007/s10792-021-02131-2
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1651-1660Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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