Turoctocog alfa pegol (N8-GP) in severe hemophilia A: Long-term safety and efficacy in previously treated patients of all ages in the pathfinder8 study.

factor VIII hemophilia A prophylaxis safety turoctocog alfa pegol

Journal

Research and practice in thrombosis and haemostasis
ISSN: 2475-0379
Titre abrégé: Res Pract Thromb Haemost
Pays: United States
ID NLM: 101703775

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 08 11 2021
revised: 13 01 2022
accepted: 17 01 2022
entrez: 21 3 2022
pubmed: 22 3 2022
medline: 22 3 2022
Statut: epublish

Résumé

N8-GP (turoctocog alfa pegol; Esperoct) is a glycoPEGylated human recombinant factor VIII (FVIII). Pathfinder8 (NCT01480180) was a phase 3, multinational, open-label, nonrandomized trial to investigate the long-term safety and efficacy of N8-GP in people of all ages with severe hemophilia A previously treated with N8-GP. Patients were recruited from the completed phase 3 pathfinder2 and pathfinder5 trials to receive intravenous N8-GP prophylaxis for up to 104 weeks, administered every 7 days, twice weekly, or three times weekly. Primary and secondary end points were the number of adverse events (AEs) reported and efficacy of treatment, respectively. Overall, 160 patients were exposed to N8-GP for a mean of 179 exposure days and 681 calendar days (≈1.9 years) per patient. In total, 119 patients experienced 510 AEs, corresponding to a rate of 1.71 AEs per patient-year of exposure; 97.5% of AEs were mild or moderate in severity, and no AEs led to withdrawal. No patients developed FVIII inhibitors during the trial. The Poisson estimate of mean annualized bleeding rate for all bleeds (excluding surgery) and across all regimens was 1.10 (median, 0.00), and for spontaneous bleeds was 0.61 (median, 0.00). Most (55.6%) patients experienced no bleeds that required FVIII treatment (excluding perioperative bleeds). The estimated hemostatic success rate for the treatment of 322 bleeding episodes (excluding surgery) was 95.8%, including missing values as failure. Long-term prophylactic use of N8-GP appeared safe and efficacious across all age groups in people with severe hemophilia A previously treated with N8-GP.

Sections du résumé

Background UNASSIGNED
N8-GP (turoctocog alfa pegol; Esperoct) is a glycoPEGylated human recombinant factor VIII (FVIII).
Objectives UNASSIGNED
Pathfinder8 (NCT01480180) was a phase 3, multinational, open-label, nonrandomized trial to investigate the long-term safety and efficacy of N8-GP in people of all ages with severe hemophilia A previously treated with N8-GP.
Patients/Method UNASSIGNED
Patients were recruited from the completed phase 3 pathfinder2 and pathfinder5 trials to receive intravenous N8-GP prophylaxis for up to 104 weeks, administered every 7 days, twice weekly, or three times weekly. Primary and secondary end points were the number of adverse events (AEs) reported and efficacy of treatment, respectively.
Results UNASSIGNED
Overall, 160 patients were exposed to N8-GP for a mean of 179 exposure days and 681 calendar days (≈1.9 years) per patient. In total, 119 patients experienced 510 AEs, corresponding to a rate of 1.71 AEs per patient-year of exposure; 97.5% of AEs were mild or moderate in severity, and no AEs led to withdrawal. No patients developed FVIII inhibitors during the trial. The Poisson estimate of mean annualized bleeding rate for all bleeds (excluding surgery) and across all regimens was 1.10 (median, 0.00), and for spontaneous bleeds was 0.61 (median, 0.00). Most (55.6%) patients experienced no bleeds that required FVIII treatment (excluding perioperative bleeds). The estimated hemostatic success rate for the treatment of 322 bleeding episodes (excluding surgery) was 95.8%, including missing values as failure.
Conclusions UNASSIGNED
Long-term prophylactic use of N8-GP appeared safe and efficacious across all age groups in people with severe hemophilia A previously treated with N8-GP.

Identifiants

pubmed: 35308099
doi: 10.1002/rth2.12674
pii: S2475-0379(22)01165-7
pmc: PMC8918113
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e12674

Informations de copyright

© 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).

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Auteurs

Steven R Lentz (SR)

Division of Hematology, Oncology, and Blood & Marrow Transplantation Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City Iowa USA.

Kaan Kavakli (K)

Department of Haematology Ege University Faculty of Medicine Children's Hospital Bornova Izmir Turkey.

Robert Klamroth (R)

Department for Internal Medicine Vascular Medicine and Haemostaseology Vivantes Klinikum im Friedrichshain Berlin Germany.

Mudi Misgav (M)

National Hemophilia Center Sheba Medical Center Tel Hashomer Israel.

Azusa Nagao (A)

Department of Blood Coagulation Ogikubo Hospital Tokyo Japan.

Alberto Tosetto (A)

Hemophilia and Thrombosis Center Hematology Department San Bortolo Hospital Vicenza Italy.

Pernille Juul Jørgensen (PJ)

Biostatistics Biopharm Novo Nordisk A/S Bagsværd Denmark.

Marek Zak (M)

Medical and Science Biopharm Novo Nordisk A/S Bagsværd Denmark.

Laszlo Nemes (L)

National Hemophilia Center and Hemostasis Department Medical Center of the Hungarian Defence Forces Budapest Hungary.

Classifications MeSH